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BMS-986144

  Cat. No.:  DC42458   Featured
Chemical Structure
1606150-08-6
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More than 5000 active chemicals with high quality for research!
Field of application
BMS-986144 is a third-generation, pan-genotype (GT) NS3/4A protease. BMS-986144 inhibits HCV replicon with EC50s of 2.3, 0.7, 1.0, 12, 8.0, and 5.8 nM for GT-1a, GT-1b, GT-2a, GT-3a, 1a R155X, and 1b D168V, respectively. BMS-986144 has the potential for the research of HCV infection.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1606150-08-6
Chemical Name: BMS-986144
SMILES: [C@@H]1(C)CCC=C[C@@H]2C[C@@]2(C(NS(=O)(=O)C2(CC2)C)=O)NC([C@@]2(C[C@@H](OC3C4C=C(F)C(=CC=4C=CN=3)OC([2H])([2H])[2H])CN2C([C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](CC)C1)=O)[H])=O
Formula: C40H51F4N5O9S
M.Wt: 856.938148736954
Purity: >98%
Sotrage: Please store the product under the recommended conditions in the Certificate of Analysis.
MSDS
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MSDS_26065_DC42458_1606150-08-6
COA
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Cat. No. Product name Field of application
DC49480 GSK8175 GSK8175 is a non-nucleoside polymerase (NS5B) inhibitor of hepatitis C virus (HCV). GSK8175 is a sulfonamide- N-benzoxaborole analog with low in vivo clearance across preclinical species and broad-spectrum activity against HCV replicons.
DC42458 BMS-986144 BMS-986144 is a third-generation, pan-genotype (GT) NS3/4A protease. BMS-986144 inhibits HCV replicon with EC50s of 2.3, 0.7, 1.0, 12, 8.0, and 5.8 nM for GT-1a, GT-1b, GT-2a, GT-3a, 1a R155X, and 1b D168V, respectively. BMS-986144 has the potential for the research of HCV infection.
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DC10104 VX222(Lomibuvir) VCH-222(Lomibuvir) is a novel, potent and selective inhibitor of HCV polymerase with IC50 of 0.94-1.2 μM, 15.3-fold less effective for mutant M423T, and 108-fold less effective for mutant I482L.
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DC10728 Pibrentasvir(ABT-530) Pibrentasvir is a novel and pan-genotypic hepatitis C virus (HCV) NS5A inhibitor with EC50s ranging from 1.4 to 5.0 pM against HCV replicons containing NS5A from genotypes 1 to 6.
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DC10818 ABT-493(Glecaprevir) Glecaprevir is a novel HCV NS3/4A protease inhibitor, with IC50 values ranging from 3.5 to 11.3 nM.
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Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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