C29

Cas No.:	363600-92-4
Chemical Name:	Tlr2-IN-C29
Synonyms:	C29;3-[[(2-hydroxy-3-methoxyphenyl)methylene]amino]-2-methyl-benzoic acid;ChemDiv3_012645;HMS1508O17;BCP20641;s6597;3-[[(E)-(5-methoxy-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]-2-methylbenzoic acid;AK687970;3-[(2-Hydroxy-3-methoxybenzylidene)amino]-2-methylbenzoic acid;3-[(2-hydroxy-3-methoxyphenyl)methy;Tlr2-IN-C29
SMILES:	O(C([H])([H])[H])C1=C([H])C([H])=C([H])C(/C(/[H])=N/C2=C([H])C([H])=C([H])C(C(=O)O[H])=C2C([H])([H])[H])=C1O[H]
Formula:	C16H15NO4
M.Wt:	285.2946
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	C29 is a Toll-like receptor 2 (TLR2) inhibitor.
In Vitro:	C29 blunts hTLR2/1 and hTLR2/6 signaling in HEK-TLR2 Stable transfectants and THP-1 Cells. C29 blocks P3C- and P2C-induced IL-8 mRNA dose-dependently in HEK-TLR2 stable transfectants. C29 also inhibits P3C- and P2C-induced IL-1β gene expression significantly at both 1 h and 4 h following stimulation, as well as both P3C- and P2C-induced NF-κB–luciferase activity in transiently transfected HEK293T cells expressing hTLR2 and an NF-κB–sensitive luciferase reporter construct. C29 preferentially inhibits TLR2/1 signaling in primary murine macrophages. C29 blocks TLR2 bacterial agonist-induced proinflammatory gene expression in HEK-TLR2 Cells and murine macrophages. C29 inhibits ligand-induced interaction of TLR2 with MyD88 and blocks MAPK and NF-κB activation[1].
References:	[1]. Vogel S, et al. Small molecule inhibitors of tlr2 signaling. WO2016164414A1