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Balamapimod

  Cat. No.:  DC10994  
Chemical Structure
863029-99-6
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More than 5000 active chemicals with high quality for research!
Field of application
Balamapimod (MKI-833) is an orally active, reversible Ras/Raf/MEK inhibitor developed for antineoplastic potential..
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 863029-99-6
Chemical Name: 4-[[3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]phenyl]amino]-6-methoxy-7-[4-(1-pyrrolidinyl)-1-piperidinyl]-3-quinolinecarbonitrile
Synonyms: MKI-833;MKI833
SMILES: N1C2C(=CC(OC)=C(N3CCC(N4CCCC4)CC3)C=2)C(NC2=CC=C(SC3N(C)C=CN=3)C(Cl)=C2)=C(C#N)C=1
Formula: C30H32ClN7Os
M.Wt: 574.144
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Balamapimod (MKI-833) is an orally active, reversible Ras/Raf/MEK inhibitor developed for antineoplastic potential.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC42418 ML786 dihydrochloride ML786 dihydrochloride potent and orally bioavailable Raf, with IC50s of 2.1, 4.2, and 2.5 nM for V600EΔB-Raf, wt B-Raf, and C-Raf, respectively. ML786 dihydrochloride also inhibits Abl-1, DDR2, EPHA2, KDR, and RET (IC50=<0.5, 7.0, 11, 6.2, 0.8 nM). ML786 dihydrochloride can be used for the research of cancers.
DC8777 CEP-32496 hydrochloride CEP-32496 Hcl is a highly potent inhibitor of BRAF(V600E/WT) and c-Raf with Kd of 14 nM/36 nM and 39 nM, also potent to Abl-1, c-Kit, Ret, PDGFRβ and VEGFR2, respectively; insignificant affinity for MEK-1, MEK-2, ERK-1 and ERK-2.
DC10994 Balamapimod Balamapimod (MKI-833) is an orally active, reversible Ras/Raf/MEK inhibitor developed for antineoplastic potential..
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