S119-8|CAS 443639-96-1|DC Chemicals

Cas No.:	443639-96-1
Chemical Name:	Benzamide, 4-(1,1-dimethylethyl)-N-[4-(phenylamino)phenyl]-
SMILES:	C(NC1=CC=C(NC2=CC=CC=C2)C=C1)(=O)C1=CC=C(C(C)(C)C)C=C1
Formula:	C₂₃H₂₄N₂O
M.Wt:	344.458
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	S119-8 is a broad spectrum inhibitor of influenza A and B viruses.
Target:	Influenza A and B[1]
In Vitro:	S119-8 is an analog of S119. S119-8 has acquired enhanced broad-spectrum activity with improved calculated physical properties, while maintaining significant potency (IC50=1.43 μM) at non-toxic (CC50=66.10 μM) concentrations, albeit somewhat higher (7-fold) than that of the parent S119 against influenza A/WSN/33 H1N1 (WSN) virus. S119-8 also shows activity against multiple influenza B viruses and an oseltamivir-resistant influenza A virus, but does not inhibit a non-influenza virus, vesicular stomatitis nirus (VSV). S119-8 has increased breadth of inhibition against influenza A and B viruses accompanied by only a small loss in potency. S119-8 inhibits influenza viruses A/Puerto Rico/8/1934 (H1N1) (PR8) with an IC50 of 6.05 μM. S119-8 inhibits influenza A/Vietnam/1203/2004 (H5N1) with an IC50 of 8.42 μM[1].
References:	[1]. White KM, et al. Broad Spectrum Inhibitor of Influenza A and B Viruses Targeting the Viral Nucleoprotein. ACS Infect Dis. 2018 Feb 9;4(2):146-157

Cat. No.	Product name	Field of application
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