TRX-0237|Hydromethylthionine;Methylene blue

Cas No.:	613-11-6
Chemical Name:	3,7-bis(dimethylamino)phenothiazin-5-ium
Synonyms:	Hydromethylthionine;Methylene blue
SMILES:	C1C2=C([S+]=C3C(=N2)C=CC(N(C)C)=C3)C=C(N(C)C)C=1
Formula:	C₁₆H₁₉N₃S
M.Wt:	285.40716
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

TRX-0237 Methylate (Hydromethylthionine, Methylene blue) is a Tau aggregation inhibitor (TAI) with Ki of 0.12 uM for intracellular TAI activity; disrupts paired helical filaments (PHFs) isolated from AD brain tissues at 0.16 uM, delays cellular senescence and enhances key mitochondrial biochemical pathways; demonstrates activities in clinical trials in Alzheimer's disease (AD) with drugs targeting β-amyloid accumulation in the brain.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC47758	Aβ Fibrillization modulator 1	Aβ Fibrillization modulator 1 stabilizes Aβ monomers.
DC46940	AZD4694	AZD4694, a fluorinated β-amyloid (Aβ) plaque neuroimaging PET radioligand, shows high affinity for Aβ fibrils (Kd = 2.3 nM).
DC46641	Methyl tridecanoate	Methyl tridecanoate moderately inhibits β-amyloid aggregation. Methyl tridecanoate weakly inhibits acetylcholinesterase (AChE).
DC45833	Aβ/tau aggregation-IN-1	Aβ/tau aggregation-IN-1 is a potent Aβ1-42 β-sheets formation and tau aggregation inhibitor. The KD values of Aβ/tau aggregation-IN-1 with Aβ1-42 and tau are 160 μM and 337 μM, respectively. Aβ/tau aggregation-IN-1 can permeate the blood-brain barrier.
DC45771	RAGE antagonist peptide TFA	RAGE antagonist peptide TFA is an advanced glycation end products (RAGE) antagonist. RAGE antagonist peptide TFA prevents RAGE from binding with several of its most important ligands, including HMGB-1, S100P, and S100A4. RAGE antagonist peptide TFA possesses anti-tumor and anti-inflammatory activities.
DC44797	Cl-NQTrp	Cl-NQTrp signifcantly disrupts the preformed fbrillar aggregates of Tau-derived PHF6 (VQIVYK) peptide and full-length tau protein.
DC44796	Beta-Amyloid(1-14),mouse,rat	Beta-Amyloid(1-14),mouse,rat is a 1 to 14 fragment of Amyloid-β peptide.
DC44795	β-Amyloid (22-40)	β-Amyloid (22-40) is a peptide fragment of β-Amyloid.
DC44794	β-Amyloid (11-22)	β-Amyloid (11-22) is a peptide fragment of β-Amyloid.
DC42447	gamma-Secretase Modulators	gamma-Secretase Modulators (Amyloid-β production) is a Amyloid-β production.