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TML-6

  Cat. No.:  DC42446  
Chemical Structure
1462868-88-7
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More than 5000 active chemicals with high quality for research!
Field of application
TML-6 inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ). TML-6 upregulates Apo E and suppresses NF-κB, mTOR. TML-6 increases the activity of the anti-oxidative Nrf2 gene. TML-6, an orally active curcumin derivative, has the potential for Alzheimer’s disease (AD) research.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1462868-88-7
Chemical Name: TML-6
SMILES: O=C(N(CC)CC)CC(C)(C(/C=C/C1=CC=C(OC)C(OC)=C1)=O)C(/C=C/C2=CC=C(OC)C(OC)=C2)=O
Formula: C30H37NO7
M.Wt: 523.62
Sotrage: 4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
MSDS
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MSDS_26053_DC42446_1462868-88-7
COA
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Cat. No. Product name Field of application
DC47758 Aβ Fibrillization modulator 1 Aβ Fibrillization modulator 1 stabilizes Aβ monomers.
DC46940 AZD4694 AZD4694, a fluorinated β-amyloid (Aβ) plaque neuroimaging PET radioligand, shows high affinity for Aβ fibrils (Kd = 2.3 nM).
DC46641 Methyl tridecanoate Methyl tridecanoate moderately inhibits β-amyloid aggregation. Methyl tridecanoate weakly inhibits acetylcholinesterase (AChE).
DC45833 Aβ/tau aggregation-IN-1 Aβ/tau aggregation-IN-1 is a potent Aβ1-42 β-sheets formation and tau aggregation inhibitor. The KD values of Aβ/tau aggregation-IN-1 with Aβ1-42 and tau are 160 μM and 337 μM, respectively. Aβ/tau aggregation-IN-1 can permeate the blood-brain barrier.
DC45771 RAGE antagonist peptide TFA RAGE antagonist peptide TFA is an advanced glycation end products (RAGE) antagonist. RAGE antagonist peptide TFA prevents RAGE from binding with several of its most important ligands, including HMGB-1, S100P, and S100A4. RAGE antagonist peptide TFA possesses anti-tumor and anti-inflammatory activities.
DC44797 Cl-NQTrp Cl-NQTrp signifcantly disrupts the preformed fbrillar aggregates of Tau-derived PHF6 (VQIVYK) peptide and full-length tau protein.
DC44796 Beta-Amyloid(1-14),mouse,rat Beta-Amyloid(1-14),mouse,rat is a 1 to 14 fragment of Amyloid-β peptide.
DC44795 β-Amyloid (22-40) β-Amyloid (22-40) is a peptide fragment of β-Amyloid.
DC44794 β-Amyloid (11-22) β-Amyloid (11-22) is a peptide fragment of β-Amyloid.
DC42447 gamma-Secretase Modulators gamma-Secretase Modulators (Amyloid-β production) is a Amyloid-β production.
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