AST-3424(OBI-3424;TH-3424)|CAS 2097713-68-1|DC Chemiclas

Cas No.:	2097713-68-1
Chemical Name:	OBI-3424
Synonyms:	3-[5-[(1S)-1-[Bis(aziridin-1-yl)phosphoryloxy]ethyl]-2-nitrophenoxy]-N,N-dimethylbenzamide;(1R)-1-{3-[3-(Dimethylcarbamoyl)phenoxy]-4-nitrophenyl}ethyl bis(1-aziridinyl)phosphinate;OBI-3424
SMILES:	P(N1CC1)(N1CC1)(=O)O[C@@H](C)C1C=CC(=C(C=1)OC1C=CC=C(C(N(C)C)=O)C=1)[N+](=O)[O-]
Formula:	C₂₁H₂₅N₄O₆P
M.Wt:	460.420165777206
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

AST-3424 (OBI-3424, TH-3424) is a first-in-class, novel prodrug that selectively targets cancers overexpressing the enzyme AKR1C3, OBI-3424 is a highly selective prodrug that is converted by AKR1C3 to a DNA alkylating agent; OBI-3424 is a nitro-benzene prodrug of N,N’-bisethylenephosphoramidate, demonstrates in vivo efficacy against preclinical xenograft models of pediatric T-ALL.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC11163	AST-3424	AST-3424 (OBI-3424, TH-3424) is a first-in-class, novel prodrug that selectively targets cancers overexpressing the enzyme AKR1C3, OBI-3424 is a highly selective prodrug that is converted by AKR1C3 to a DNA alkylating agent.