S130|ATG4B inhibitor S130

Cas No.:	1160852-22-1
Chemical Name:	N-(3-(diethylamino)propyl)-7-oxo-7H-dibenzo[de,g]quinoline-4-carboxamide
Synonyms:	ATG4B inhibitor S130
SMILES:	N1C2=C3C(=CC=CC3=C(C(NCCCN(CC)CC)=O)C=1)C1=CC=CC=C1C2=O
Formula:	C₂₄H₂₅N₃O₂
M.Wt:	387.483
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

S130 (ATG4B inhibitor S130) is a potent, specific ATG4B inhibitor with IC50 of 3.24 uM, shows strong affinity (Kd=4 uM) and specifically suppresses the activity of ATG4B, but not other proteases; displays no inhibitory effects on cysteine proteases such as CASP3 (caspase 3), CASP8 (caspase 8) and CASP9 (caspase 9), or aspartic proteases; does not cause the impairment of autophagosome fusion, nor does it result in the dysfunction of lysosomes; causes cell death of colorectal cancer cells in vitro and in vivo.

COA

MSDS

Cat. No.	Product name	Field of application
DC11255	S130	S130 (ATG4B inhibitor S130) is a potent, specific ATG4B inhibitor with IC50 of 3.24 uM, shows strong affinity (Kd=4 uM) and specifically suppresses the activity of ATG4B, but not other proteases.
DC11172	LV-320	LV-320 (LV320) is a novel potent, cell-active, allosteric inhibitor of the autophagy-related cysteine protease ATG4B with IC50 of 24.5 uM in ATG4B cleavage assays.