γ-secretase modulator 14a|

Cas No.:	1485066-18-9
Chemical Name:	N-(4-fluorophenyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazol-7-amine
SMILES:	O1C2C(NC3=CC=C(F)C=C3)CCCC=2C(C2=CC=C(N3C=NC(C)=C3)C(OC)=C2)=N1
Formula:	C₂₄H₂₃FN₄O₂
M.Wt:	418.472
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent, selective, orally active γ-secretase modulator with Aβ42 IC50 of 39 nM; shows good to excellent selectivity for the reduction of Aβ42 in the cellular assays; significantly reduces Aβ42 in the CNS compartment in vivo in nontransgenic rat models.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC46415	BPN-15606 besylate	BPN-15606 besylate is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC50 values of 7 nM and 17nM, respectively. BPN-15606 besylate lowers Aβ42 and Aβ40 levels in the central nervous system of rats and mice. BPN-15606 besylate has acceptable PK/PD properties, including bioavailability, half-life, and clearance.
DC46244	γ-Secretase modulator 4	γ-Secretase modulator 4 is a potent γ-secretase modulator, reduces the Aβ42 level with IC50s of 0.014 μM and 0.017 μM in human and mouse, respectively.
DC42429	LY-411575 (isomer 2)	LY-411575 isomer 2 is an isomer of LY411575, which is a potent γ-secretase.
DC42428	Ilorasertib	Ilorasertib (ABT-348) is a potent and ATP-competitive multitargeted kinase, which inhibits Aurora C, Aurora B, and Aurora A with IC50s of 1 nM, 7 nM, 120 nM, respectively. Ilorasertib also suppresses RET tyrosine kinase, PDGFRβ and Flt1 with IC50s of 7 nM, 3 nM and 32 nM, respectively.
DC41016	Aβ42-IN-2	Aβ42-IN-2 is a γ-secretase modulators extracted from patent WO2016070107, compound example 36. Aβ42-IN-2 has an IC50 of 6.5 nM for Αβ42. Aβ42-IN-2 can be used for the research of a disorder associated with aberrant A3 peptide levels, including Alzheimer's disease.
DC28676	Aβ42-IN-1 free base	Aβ42-IN-1 free base (compound 1v) is an orally active, high brain exposure γ-secretase modulator. Aβ42-IN-1 free base potently reduces Aβ42 levels with an IC50 value of 0.091 µM, and significantly reduces brain Aβ42 levels in mice. Aβ42-IN-1 free base is a promising compound for the treatment of Alzheimer’s disease.
DC28675	Aβ42-IN-1	Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM). Aβ42-IN-1 potently reduced Aβ42 levels with an IC50 value of 0.091 µM without CYP3A4 inhibition. Aβ42-IN-1 shows a sustained pharmacokinetic profile.
DC28074	gamma-secretase modulator 1 hydrochloride	gamma-secretase inhibitior-1 is a gamma-secretase modulator, γ-secretase inhibitior-1 is useful for Alzheimer's disease.
DC11615	γ-secretase modulator 14a	A potent, selective, orally active γ-secretase modulator with Aβ42 IC50 of 39 nM.