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| Cas No.: | 854847-61-3 |
| Chemical Name: | 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine |
| Synonyms: | HLY78;HLY 78 |
| SMILES: | C1=C2C(N(C)CC3=C2C=C2OCOC2=C3)=C(CC)C=C1 |
| Formula: | C17H17NO2 |
| M.Wt: | 267.3 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | An activator of the Wnt/β-catenin signaling pathway that targets the DIX domain of Axin; potentiates the Axin-LRP6 association, thus promoting LRP6 phosphorylation and Wnt signaling transduction; acts synergistically with Wnt in the embryonic development of zebrafish and increases the expression of the conserved hematopoietic stem cell (HSC) markers, runx1 and cmyb, in zebrafish embryos. |
| Target: | Wnt/β-catenin[1] |
| References: | [1]. Wang S, et al. Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction. Nat Chem Biol. 2013 Sep;9(9):579-85. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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