HLY-78|CAS 854847-61-3|DC Chemicals

Cas No.:	854847-61-3
Chemical Name:	4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine
Synonyms:	HLY78;HLY 78
SMILES:	C1=C2C(N(C)CC3=C2C=C2OCOC2=C3)=C(CC)C=C1
Formula:	C₁₇H₁₇NO₂
M.Wt:	267.3
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	An activator of the Wnt/β-catenin signaling pathway that targets the DIX domain of Axin; potentiates the Axin-LRP6 association, thus promoting LRP6 phosphorylation and Wnt signaling transduction; acts synergistically with Wnt in the embryonic development of zebrafish and increases the expression of the conserved hematopoietic stem cell (HSC) markers, runx1 and cmyb, in zebrafish embryos.
Target:	Wnt/β-catenin[1]
References:	[1]. Wang S, et al. Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction. Nat Chem Biol. 2013 Sep;9(9):579-85.

Cat. No.	Product name	Field of application
DC11651	HLY-78	HLY78 is an activator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signaling transduction[1].