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| Cas No.: | 881639-98-1 |
| Chemical Name: | G-1 |
| Synonyms: | G-1;(±)-1-[(3aR*,4S*,9bS*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]-ethanone;1-[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]ethanone;rel-1-[(3aR,4S,9bS)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]ethanone (ACI);G 1;G 1 (Anti-tumor agent);G1 |
| SMILES: | BrC1C=C2OCOC2=CC=1[C@@H]1NC2C=CC(=CC=2[C@@H]2C=CC[C@H]12)C(=O)C |
| Formula: | C21H18BrNO3 |
| M.Wt: | 412.276525020599 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | A potent and selective GPER/GPR30 agonist with Ki of 11 nM, EC50 of 2 nM; displays no activity at ERα and ERβ at concentrations up to 10 uM; increases cytosolic Ca2+ and inhibits migration of SKBr3 cells and MCF-7 cells in response to chemoattractants with IC50 of 0.7 and 1.6 nM respectively; induces cell cycle arrest, DNA damage and cell death by the activation of the intrinsic apoptotic mechanism in H295R cells. |