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| Cas No.: | 1803274-65-8 |
| Chemical Name: | 3-(2-((4-(trifluoromethoxy)phenyl)amino)-1-((1R,5R)-3,3,5-trimethylcyclohexyl)-1H-benzo[d]imidazol-5-yl)propanoic acid |
| Synonyms: | BAY1436032;BAY 1436032 |
| SMILES: | C(O)(=O)CCC1=CC=C2C(=C1)N=C(NC1=CC=C(OC(F)(F)F)C=C1)N2[C@H]1C[C@@H](C)CC(C)(C)C1 |
| Formula: | C26H30F3N3O3 |
| M.Wt: | 489.54 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | BAY-1436032 (BAY1436032) is a potent, selective, orally available inhibitor of pan-mutant IDH1 with IC50 of 15 nM for both IDH1 R132H and R132C, respectively; shows no effect on wild-type IDH1; strongly reduces 2-HG levels in cells carrying IDH1-R132H, -R132C, -R132G, -R132S and -R132L mutations; significantly prolongs survival of mice intracerebrally transplanted with human astrocytoma carrying the IDH1R132H mutation. |