AZ-8838|AZ 8838;AZ8838

Cas No.:	2100285-41-2
Chemical Name:	(S)-(4-fluoro-2-propylphenyl)(1H-imidazol-2-yl)methanol
Synonyms:	AZ 8838;AZ8838
SMILES:	[C@@H](C1=CC=C(F)C=C1CCC)(C1NC=CN=1)O
Formula:	C₁₃H₁₅FN₂O
M.Wt:	234.274
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

AZ-8838 (AZ8838) is a potent, and selective PAR2 antagonist with Kd of 125 nM; shows excellent selectivity over PAR1 and PAR4 (>50 uM).

Cat. No.	Product name	Field of application
DC70677	PAR2 antagonist C391	PAR2 antagonist C391 (C391) is a selective PAR2 antagonist, potently inhibits peptidomimetic-induced PAR2 Ca2+ signalling with IC50 of 1.3 uM.C391 blocks both PAR2 Ca2+ and MAPK signalling pathways activated by peptidomimetics and/or proteinase activation.C391 effectively attenuated compound 48/80-induced thermal hyperalgesia in vivo.C391 blocked A. alternata-induced, PAR2-dependent Ca2+ and MAPK signalling in 16HBE14o- cells, as well as β-arrestin recruitment in HEK 293 cells.C391 effectively attenuated A. alternata-induced inflammation, mucus production, mucus cell hyperplasia and airway hyperresponsiveness in acute allergen-challenged murine models.
DC41699	FSLLRY-NH2	FSLLRY-NH2 is a protease-activated receptor 2 (PAR2) inhibitor.
DC11742	AZ-8838	AZ-8838 (AZ8838) is a potent, and selective PAR2 antagonist with Kd of 125 nM.