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JP-153

  Cat. No.:  DC11954   Featured
Chemical Structure
1802937-26-3
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More than 5000 active chemicals with high quality for research!
Field of application
JP-153 (JP153) is a novel small molecule targets the Src-FAK-Paxillin signaling, inhibits Src-dependent phosphorylation of paxillin (Y118) and downstream activation of Akt (S473) in RECs; potently inhibits VEGF-induced proliferation and migration, inhibits retinal neovascularization in the murine oxygen-induced retinopathy model.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1802937-26-3
Chemical Name: 4-(3,4,5-trimethoxyphenyl)-1,4-dihydro-2H-naphtho[1,2-d][1,3]oxazin-2-one
Synonyms: JP 153;JP153
SMILES: O1C(C2=CC(OC)=C(OC)C(OC)=C2)C2=CC=C3C(=C2NC1=O)C=CC=C3
Formula: C21H19NO5
M.Wt: 365.385
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: References 1. Toutounchian JJ, et al. Mol Pharmacol. 2017 Jan;91(1):1-13. View Related Products by Target Src
Description: JP-153 (JP153) is a novel small molecule targets the Src-FAK-Paxillin signaling, inhibits Src-dependent phosphorylation of paxillin (Y118) and downstream activation of Akt (S473) in RECs; potently inhibits VEGF-induced proliferation and migration, inhibits retinal neovascularization in the murine oxygen-induced retinopathy model.
References: References 1. Toutounchian JJ, et al. Mol Pharmacol. 2017 Jan;91(1):1-13. View Related Products by Target Src
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC7571 PD173955 PD-173955 is a src tyrosine kinase inhibitor. PD173955 inhibited Bcr-Abl-dependent cell growth.
DC11954 JP-153 JP-153 (JP153) is a novel small molecule targets the Src-FAK-Paxillin signaling, inhibits Src-dependent phosphorylation of paxillin (Y118) and downstream activation of Akt (S473) in RECs; potently inhibits VEGF-induced proliferation and migration, inhibits retinal neovascularization in the murine oxygen-induced retinopathy model.
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