2′-Deoxyadenosine 5′-monophosphate disodium|CAS 2922-74-9|DC Chemicals

Cas No.:	2922-74-9
Chemical Name:	2'-Deoxyadenosine-5'-monophosphate
Synonyms:	2'-deoxyadenosine 5'-monophosphate disodium salt;2'-Deoxyadenosine-5'-monophosphate disodium salt;Sodium ((2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxytetrahydrofuran-2-yl)methyl phosphate;disodium 2'-deoxyadenosine 5'-monophosphate;Adenosine,2'-deoxy-, 5'-(dihydrogen phosphate), disodium salt (8CI);Adenosine,2'-deoxy-, 5'-phosphate, disodium salt (7CI);Deoxyadenosine 5'-monophosphatedisodium salt;2'-deoxyadenosine-5'-monophosphate;dAMP;2'-Deoxyadenosine 5'-monophosphate;2'-Deoxyadenylic acid;2'-Deoxyadenosine 5'-phosphate;Deoxyadenylic acid;Deoxy-AMP;Deoxyadenosine monophosphate;2'-Deoxy-AMP;Deoxyadenosine 5'-monophosphate;5'-Adenylic acid, 2'-deoxy-;2'-dAMP;Deoxyadenosine 5'-phosphate;Poly dAP;Deoxy-5'-adenylic acid;Poly(dA);2'-Deoxyadenosine monophosphate;2'-DEOXY-5'-ADENYLIC ACID;Oligo(dA);2'-Deoxy-5'-adenosine monophosphate;(dA)n;Poly(deoxyadenylic acid);2-Deoxyadenosine-5-m
SMILES:	OP(=O)(O)OC[C@H]1O[C@H](C[C@@H]1O)N2C3=C(C(N)=NC=N3)N=C2
Formula:	C₁₀H₁₄N₅O₆P
M.Wt:	331.2218
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	2′-Deoxyadenosine 5′-monophosphate disodium, a nucleic acid AMP derivative, is a deoxyribonucleotide found in DNA. 2′-Deoxyadenosine 5′-monophosphate disodium can be used to study adenosine-based interactions during DNA synthesis and DNA damage[1].
In Vitro:	2′-Deoxyadenosine 5′-monophosphate (dAMP) is incorporated into Caco-2 cells in a time-dependent manner. The uptake of 2′-Deoxyadenosine 5′-monophosphate is increased with a drop in pH, suggesting that 2′-Deoxyadenosine 5′-monophosphate transport activity might be linked to the protons. 2′-Deoxyadenosine 5′-monophosphate uptake by Caco-2 cells is pH- and Na+-dependent[1].
References:	[1]. Katsuya Narumi, et al. Mutual role of ecto-5'-nucleotidase/CD73 and concentrative nucleoside transporter 3 in the intestinal uptake of dAMP. PLoS One. 2019 Oct 21;14(10):e0223892. [2]. V Duarte, et al. Insertion of dGMP and dAMP during in vitro DNA synthesis opposite an oxidized form of 7,8-dihydro-8-oxoguanine. Nucleic Acids Res. 1999 Jan 15;27(2):496-502.

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