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STING inhibitor-1

  Cat. No.:  DC60034   Featured
Chemical Structure
727699-84-5
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More than 5000 active chemicals with high quality for research!
Field of application
STING inhbiitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING-​mediated disease.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 727699-84-5
Chemical Name: SN-001
Synonyms: N-(3-(4-fluorophenylsulfonamido)-4-methoxyphenyl)-[1,1'-biphenyl]-4-carboxamide;N-[3-[(4-fluorophenyl)sulfonylamino]-4-methoxyphenyl]-4-phenylbenzamide;MLS000417014;SMR000241960;N-[3-(4-fluorobenzenesulfonamido)-4-methoxyphenyl]-4-phenylbenzamide;MLS003912103;cid_5020799;BDBM113889;HMS2575B12;CEB69984;N-[3-[(4-fluorophenyl)sulfonylamino]-4-methoxy-phenyl]-4-phenyl-benzamide;F2063;n-(3-((4-fluorophenyl)sulfonylamino)-4-methoxyphenyl)-4-phenylbenzamide;N-[3-[(4-fluorophenyl)sulfonylamino]-4-metho;SN-001
SMILES: S(C1C([H])=C([H])C(=C([H])C=1[H])F)(N([H])C1=C(C([H])=C([H])C(=C1[H])N([H])C(C1C([H])=C([H])C(=C([H])C=1[H])C1C([H])=C([H])C([H])=C([H])C=1[H])=O)OC([H])([H])[H])(=O)=O
Formula: C26H21FN2O4S
M.Wt: 476.5193
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_29526_DC60034_727699-84-5
COA
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Cat. No. Product name Field of application
DC60034 STING inhibitor-1 STING inhbiitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING-​mediated disease.
DC60033 STING INHIBITOR-2 STING inhbiitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING-​mediated disease.
DC39220 STING agonist compound 17 STING agonist compound 17 is a selective stimulator of interferon genes (STING) receptor agonist.
DC39210 MSA-2 analogue MSA-2 analogue is an orally available human STING agonist.
DC39031 MSA-2 MSA-2 is an orally available human STING agonist.MSA-2 is bound to STING as a noncovalent dimer. Extensive experimental analysis indicates that MSA-2 predimerization is required for binding. Acidic tumor microenvironments favor permeable, uncharged MSA-2.
DC39030 SR-717 (lithium salt) SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic.
DC72041 BSP16 BSP16 is a potent, orally active stimulator of interferon genes (STING) agonist. BSP16 can selectively stimulate the STING pathway. BSP16 can be used for the research of cancer.
DC50039 3'3'-cGAMP (sodium salt) 3’3’-cGAMP Fluorinated (c-[2'FdGMP]-[2'FdAMP]) is a synthetic analog of cyclic guanosine monophosphate- adenosine monophosphate (cyclic GMP-AMP, cGAMP) with a fluorine atom at 2’ position of the nucleosides. 3’3’-cGAMP is a cyclic di-nucleotide produced by bacteria. It is also referred to as "canonical" cGAMP due the presence of the classical 3’-5’ phosphodiester linkages between the guanosine and the adenosine. It has been reported that cGAMP binds STING (stimulator of IFN genes) and subsequently induces TBK1-IRF3-dependent production of IFN-β [1]. The incorporation of fluorine into biologically active molecules is commonly used in medicinal chemistry to improve their metabolic stability or to modulate physicochemical properties such as lipophilicity [2, 3]. Moreover, the introduction of a fluorine atom can change the biological activities of a molecule. Interestingly, when used at low concentrations in various cellular assays, 3’3’-cGAMP Fluorinated induces higher levels of type I IFNs than does cGAMP. STING ligands such as cGAMP induce type I IFNs and activate interferon stimulated genes (ISG) through IRFs. To facilitate their study, InvivoGen has developed stable reporter cells in two well established immune cell models: THP-1 human monocytes and RAW 264.7 murine macrophages. These cells express a reporter gene (SEAP or Lucia luciferase), under control of an IRF-inducible promoter.
DC49673 STING agonist-7 STING agonist-7 is a non-nucleotide STING agonist. STING agonist-7 binds selectively to mouse STING but not human STING. STING agonist-7 penetrates cell membrane poorly.
DC48024 cGAMP diammonium cGAMP (Cyclic GMP-AMPP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators.
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