PI-2620 precursor |CAS 2173361-83-4 |DC Chemicals

Cas No.:	2173361-83-4
Chemical Name:	tert-butyl 11-(2-nitropyridin-4-yl)-4,8,10-triazatricyclo7.4.0.0,2,7trideca-1(9),2(7),3,5,10,12-hexaene-8-carboxylate
Synonyms:	tert-butyl 11-(2-nitropyridin-4-yl)-4,8,10-triazatricyclo[7.4.0.0,2,7]trideca-1(9),2(7),3,5,10,12-hexaene-8-carboxylate;EN300-27102127;2173361-83-4;tert-butyl 11-(2-nitropyridin-4-yl)-4,8,10-triazatricyclo[7.4.0.0 ,?]trideca-1(9),2(7),3,5,10,12-hexaene-8-carboxylat e;9H-Pyrido[3',4':4,5]pyrrolo[2,3-b]pyridine-9-carboxylic acid, 2-(2-nitro-4-pyridinyl)-, 1,1-dimethylethyl ester;tert-butyl 11-(2-nitropyridin-4-yl)-4,8,10-triazatricyclo7.4.0.0,2,7trideca-1(9),2(7),3,5,10,12-hexaene-8-carboxylate
SMILES:	O(C(N1C2C=CN=CC=2C2=CC=C(C3C=CN=C(C=3)[N+](=O)[O-])N=C12)=O)C(C)(C)C
Formula:	C₂₀H₁₇N₅O₄
M.Wt:	391.380083799362
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

MSDS

Cat. No.	Product name	Field of application
DC67548	NOP-1A	NOP-1A standard. 11C-NOP-1A is a new radioligand for thenociceptin/orphanin FQ peptide (NOP) receptor, with high affinity (Ki, 0.15 nM) and appropriate lipophilicity (measured logD, 3.4) for PET brain imaging. 11C-NOP-1A is the the first successful radioligand to image NOP receptors in rat and monkey brain. 11C-NOP-1A is a selective antagonist at the NOP receptor and has high affinity and appropriate lipophilicity for blood–brain barrier permeability. 11C-NOP-1A imaging in rhesus monkeys showed high brain uptake and a large receptor-specific signal and could be quantified with the gold standard method of compartmental modeling. In humans 1C-NOP-1A reliably quantified NOP receptors in human brain both in large brain regions and at a voxelwise level using parametric imaging. The radiation absorbed dose in humans was similar to that observed with other 11C-labeled ligands and would allow multiple scans of a single subject. Thus, 11C-NOP-1A is a promising radioligand for reliably quantifying NOP receptors in human brain.
DC67547	NOP-1A Precursor	The Precursor of NOP-1A. (11)C-NOP-1A is a useful radioligand for quantifying NOP receptors in the monkey brain, and its radiation dose is similar to that of other (11)C-labeled ligands for neuroreceptors.
DC67437	PI-2620 precursor	PI-2620 precursor is the precursor of PI2620. 18F-PI-2620 is a PET tracer with high binding affinity for aggregated tau, a key pathologic feature of Alzheimer disease (AD) and other neurodegenerative disorders.
DC60818	mono-Boc-Br MK-6240 Precursor	mono-Boc-Br MK-6240 Precursor is the precusor of MK-6240.. (18)F]-MK-6240 is a tau positron emission tomography (PET) tracer for neurofibrillary tangles (NFTs), exhibiting high specificity and selectivity for binding to NFTs .
DC67285	DOTA-Octreotide
DC67284	NOTA-NOC
DC60791	Cholestify Precursor	Precursor of Cholestify,18F-Cholestify, which binds cytochrome P450 46A1, detected cholesterol breakdown in the mammalian brain. CYP46A1 converts cholesterol to 24-hydroxycholesterol, a form easily eliminated from the brain.
DC60790	DesMEM AZD4694	DesMEM AZD4694（AZD4694 Precursor 1）is the precursor of [18F] AZD4694 for the synthesis of [18F] AZD4694, an amyloid-β imaging ligand with high affinity for amyloid-β plaques.
DC66469	DOTA-NOC	DOTA-NOC (DOTA-Nal3-octreotide) is a high-affinity ligand of somatostatin receptor subtypes 2, 3 and 5. DOTA-NOC can be used for labeling with various radiometals, and development of radiopeptide imaging.
DC66468	NOTA-octreotide	NOTA-octreotide is a ligand for making [18F]AlF-NOTA-octreotide, which is a PET/CT imaging agent for somatostatin receptor imaging in neuroendocrine tumor patients