Thalidomide-O-amido-C3-COOH|CAS 2308035-51-8|DC Chemicals

Cas No.:	2308035-51-8
Chemical Name:	Thalidomide-O-amido-C3-COOH
Synonyms:	Thalidomide-O-amido-C3-COOH;Thalidomide-O-amido-C3-carboxylic acid;E3 Ligase Ligand-Linker Conjugates 15;4-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butanoic acid;Thalidomide-O-amido-C3-carboxylic acid;Cereblon Ligand-Linker Conjugates 7; E3 ligase Ligand-Linker Conjugates 15;4-[[2-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]oxyacetyl]amino]butanoic acid;4-[[2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetyl]amino]butanoic acid;2308035-51-8;AT18332;HY-103612;CS-7754;Thalidomide-O-acetamido-C3-acid;4-(2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxy}acetamido)butanoic acid;BCP33437;AKOS037653310;SCHEMBL23636449;A1-29431;EX-A3942
SMILES:	O(C([H])([H])C(N([H])C([H])([H])C([H])([H])C([H])([H])C(=O)O[H])=O)C1=C([H])C([H])=C([H])C2=C1C(N(C2=O)C1([H])C(N([H])C(C([H])([H])C1([H])[H])=O)=O)=O
Formula:	C₁₉H₁₉N₃O₈
M.Wt:	417.3695
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC67720	Pomalidomide-C7-NH2 hydrochloride	Pomalidomide-C7-NH2 (Pomalidomide 4'-alkylC7-amine) hydrochloride is an E3 ligase ligand-linker conjugate. Pomalidomide-C7-NH2 hydrochloride can be used for the synthesis of PROTAC.
DC67719	(S,R,S)-CO-C2-acid	(S,R,S)-CO-C2-acid (VH 032 amide-alkylC2-acid) is a functionalized von-Hippel-Lindau (VHL) protein ligand that can be used in PROTAC research and development. (S,R,S)-CO-C2-acid contains an E3 ligand alkyl ligand for conjugation of target protein ligands.
DC67718	E3 ligase Ligand 32	E3 ligase Ligand 32 (First product in Example 52) is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 32 can be connected to the ligand for protein by a linker to form PROTACs and can be used for the synthesis of PROTAC SMARCA2/4-degrader-29 (HY-162743).
DC67717	1H-Indazole-4-carboxamide, 6-bromo-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1-methylethyl)-
DC67716	(S,R,S)-AHPC-PEG2-C4-Cl	(S,R,S)-AHPC-PEG2-C4-Cl (VH032-PEG2-C4-Cl) is a conjugate of ligands for E3 and 13-atom-length linker. The connector of linker is Halogen group. (S,R,S)-AHPC-PEG2-C4-Cl incorporates the (S,R,S)-AHPC based VHL ligand and an alkyl/ether-based linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays.
DC67715	E3 ligase Ligand 9	E3 ligase Ligand 9 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 9 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.
DC67714	WAY-620124
DC67713	VH 032 amide-alkylC6-acid	VH 032 amide-alkylC6-acid ((S,R,S)-AHPC-CO-C6-COOH) is a VH032 analog that acts as a ligand for VHL, recruiting von Hippel-Lindau (VHL) protein. VH 032 amide-alkylC6-acid can be used in the synthesis of PROTACs.
DC67712	2-(2,6-dioxopiperidin-3-yl)-5-ethynyl-2,3-dihydro-1H-isoindole-1,3-dione	2-(2,6-Dioxopiperidin-3-yl)-5-ethynylisoindoline-1,3-dione is a Thalidomide analog that can be useful in PROTAC research.
DC67708	(S,R,S)-AHPC-C3-COOH	(S,R,S)-AHPC-C3-COOH (compound 28i) is a carboxylic acid derivative of the VHL E3 ubiquitin ligase ligand-Linker conjugate. (S,R,S)-AHPC-C3-COOH can be used to synthesize PROTACs.