3-(5-bromo-1-oxo-2,3-dihydro-1H-isoindol-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}piperidine-2,6-dione|CAS 2409004-53-9|DC Chemicals

Cas No.:	2409004-53-9
Chemical Name:	3-(5-bromo-1-oxo-2,3-dihydro-1H-isoindol-2-yl)-1-{2-(trimethylsilyl)ethoxymethyl}piperidine-2,6-dione
Synonyms:	2409004-53-9;3-(5-bromo-1-oxo-2,3-dihydro-1H-isoindol-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}piperidine-2,6-dione;EN300-33051130;2,6-Piperidinedione, 3-(5-bromo-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-1-[[2-(trimethylsilyl)ethoxy]methyl]-;3-(5-Bromo-1-oxoisoindolin-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)piperidine-2,6-dione;3-(5-bromo-1-oxo-2,3-dihydro-1H-isoindol-2-yl)-1-{2-(trimethylsilyl)ethoxymethyl}piperidine-2,6-dione;3-(5-Bromo-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-1-[[2-(trimethylsilyl)ethoxy]methyl]-2,6-piperidinedione;G75742;DB-377979
SMILES:	BrC1C=CC2C(N(CC=2C=1)C1C(N(COCC[Si](C)(C)C)C(CC1)=O)=O)=O
Formula:	C₁₉H₂₅BrN₂O₄Si
M.Wt:	453.402305364609
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC67720	Pomalidomide-C7-NH2 hydrochloride	Pomalidomide-C7-NH2 (Pomalidomide 4'-alkylC7-amine) hydrochloride is an E3 ligase ligand-linker conjugate. Pomalidomide-C7-NH2 hydrochloride can be used for the synthesis of PROTAC.
DC67719	(S,R,S)-CO-C2-acid	(S,R,S)-CO-C2-acid (VH 032 amide-alkylC2-acid) is a functionalized von-Hippel-Lindau (VHL) protein ligand that can be used in PROTAC research and development. (S,R,S)-CO-C2-acid contains an E3 ligand alkyl ligand for conjugation of target protein ligands.
DC67718	E3 ligase Ligand 32	E3 ligase Ligand 32 (First product in Example 52) is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 32 can be connected to the ligand for protein by a linker to form PROTACs and can be used for the synthesis of PROTAC SMARCA2/4-degrader-29 (HY-162743).
DC67717	1H-Indazole-4-carboxamide, 6-bromo-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1-methylethyl)-
DC67716	(S,R,S)-AHPC-PEG2-C4-Cl	(S,R,S)-AHPC-PEG2-C4-Cl (VH032-PEG2-C4-Cl) is a conjugate of ligands for E3 and 13-atom-length linker. The connector of linker is Halogen group. (S,R,S)-AHPC-PEG2-C4-Cl incorporates the (S,R,S)-AHPC based VHL ligand and an alkyl/ether-based linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays.
DC67715	E3 ligase Ligand 9	E3 ligase Ligand 9 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 9 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.
DC67714	WAY-620124
DC67713	VH 032 amide-alkylC6-acid	VH 032 amide-alkylC6-acid ((S,R,S)-AHPC-CO-C6-COOH) is a VH032 analog that acts as a ligand for VHL, recruiting von Hippel-Lindau (VHL) protein. VH 032 amide-alkylC6-acid can be used in the synthesis of PROTACs.
DC67712	2-(2,6-dioxopiperidin-3-yl)-5-ethynyl-2,3-dihydro-1H-isoindole-1,3-dione	2-(2,6-Dioxopiperidin-3-yl)-5-ethynylisoindoline-1,3-dione is a Thalidomide analog that can be useful in PROTAC research.
DC67708	(S,R,S)-AHPC-C3-COOH	(S,R,S)-AHPC-C3-COOH (compound 28i) is a carboxylic acid derivative of the VHL E3 ubiquitin ligase ligand-Linker conjugate. (S,R,S)-AHPC-C3-COOH can be used to synthesize PROTACs.