2-(2,6-dioxopiperidin-3-yl)-5-ethynyl-2,3-dihydro-1H-isoindole-1,3-dione|CAS 2154356-63-3|DC Chemicals

Cas No.:	2154356-63-3
Chemical Name:	2-(2,6-dioxopiperidin-3-yl)-5-ethynyl-2,3-dihydro-1H-isoindole-1,3-dione
Synonyms:	O=C1NC(CCC1N1C(C2=CC=C(C=C2C1=O)C#C)=O)=O;2-(2,6-Dioxopiperidin-3-yl)-5-ethynylisoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-ethynyl-2,3-dihydro-1H-isoindole-1,3-dione;SY289233;BP-27970;MFCD32853087;SY288265;SY289232;EN300-7459357;(S)-2-(2,6-Dioxopiperidin-3-yl)-5-ethynylisoindoline-1,3-dione;SCHEMBL19585422;(R)-2-(2,6-Dioxopiperidin-3-yl)-5-ethynylisoindoline-1,3-dione;AKOS040766189;2-(2,6-dioxopiperidin-3-yl)-5-ethynylisoindole-1,3-dione;Z3990526756;2154356-63-3;F72015;F1957-0838
SMILES:	O=C1C(CCC(N1)=O)N1C(C2C=CC(C#C)=CC=2C1=O)=O
Formula:	C₁₅H₁₀N₂O₄
M.Wt:	282.250903606415
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC67720	Pomalidomide-C7-NH2 hydrochloride	Pomalidomide-C7-NH2 (Pomalidomide 4'-alkylC7-amine) hydrochloride is an E3 ligase ligand-linker conjugate. Pomalidomide-C7-NH2 hydrochloride can be used for the synthesis of PROTAC.
DC67719	(S,R,S)-CO-C2-acid	(S,R,S)-CO-C2-acid (VH 032 amide-alkylC2-acid) is a functionalized von-Hippel-Lindau (VHL) protein ligand that can be used in PROTAC research and development. (S,R,S)-CO-C2-acid contains an E3 ligand alkyl ligand for conjugation of target protein ligands.
DC67718	E3 ligase Ligand 32	E3 ligase Ligand 32 (First product in Example 52) is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 32 can be connected to the ligand for protein by a linker to form PROTACs and can be used for the synthesis of PROTAC SMARCA2/4-degrader-29 (HY-162743).
DC67717	1H-Indazole-4-carboxamide, 6-bromo-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1-methylethyl)-
DC67716	(S,R,S)-AHPC-PEG2-C4-Cl	(S,R,S)-AHPC-PEG2-C4-Cl (VH032-PEG2-C4-Cl) is a conjugate of ligands for E3 and 13-atom-length linker. The connector of linker is Halogen group. (S,R,S)-AHPC-PEG2-C4-Cl incorporates the (S,R,S)-AHPC based VHL ligand and an alkyl/ether-based linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays.
DC67715	E3 ligase Ligand 9	E3 ligase Ligand 9 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 9 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.
DC67714	WAY-620124
DC67713	VH 032 amide-alkylC6-acid	VH 032 amide-alkylC6-acid ((S,R,S)-AHPC-CO-C6-COOH) is a VH032 analog that acts as a ligand for VHL, recruiting von Hippel-Lindau (VHL) protein. VH 032 amide-alkylC6-acid can be used in the synthesis of PROTACs.
DC67712	2-(2,6-dioxopiperidin-3-yl)-5-ethynyl-2,3-dihydro-1H-isoindole-1,3-dione	2-(2,6-Dioxopiperidin-3-yl)-5-ethynylisoindoline-1,3-dione is a Thalidomide analog that can be useful in PROTAC research.
DC67708	(S,R,S)-AHPC-C3-COOH	(S,R,S)-AHPC-C3-COOH (compound 28i) is a carboxylic acid derivative of the VHL E3 ubiquitin ligase ligand-Linker conjugate. (S,R,S)-AHPC-C3-COOH can be used to synthesize PROTACs.