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(S,R,S)-AHPC-O-Ph-PEG1-NH2

  Cat. No.:  DC67816   Featured
Chemical Structure
2361117-24-8
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Field of application
(S,R,S)-AHPC-O-Ph-PEG1-NH2 (VH032-O-Ph-PEG1-NH2) is E3 ligase ligand-linker conjugate and incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-O-Ph-PEG1-NH2 is used in PROTAC EED degrader-1 (HY-130614). PROTAC EED degrader-1 is a PROTAC targeting EED with a pKD of 9.02.
Cas No.: 2361117-24-8
Chemical Name: (S,R,S)-AHPC-O-Ph-PEG1-NH2
Synonyms: (S,R,S)-AHPC-O-Ph-PEG1-NH2;VH032-O-Ph-PEG1-NH2;BCP33432;(2S,4R)-1-((S)-2-(2-(4-(2-aminoethoxy)phenoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;SCHEMBL21069055;CS-0114227;EX-A3936;AKOS040743872;DA-59709;2361117-24-8;(2S,4R)-1-[(2S)-2-[[2-[4-(2-aminoethoxy)phenoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide;MS-30807;HY-130816;F82548
SMILES: S1C=NC(C)=C1C1C=CC(=CC=1)CNC([C@@H]1C[C@H](CN1C([C@H](C(C)(C)C)NC(COC1C=CC(=CC=1)OCCN)=O)=O)O)=O
Formula: C32H41N5O6S
M.Wt: 623.762846708298
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
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