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Pomalidomide-PEG2-azide

  Cat. No.:  DC67980   Featured
Chemical Structure
2267306-14-7
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More than 5000 active chemicals with high quality for research!
Field of application
Pomalidomide-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1]. Pomalidomide-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Cas No.: 2267306-14-7
Chemical Name: Pomalidomide-PEG2-azide
Synonyms: 2-[2-(2-Azidoethoxy)ethoxy]-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]acetamide;Pomalidomide-PEG2-azide;2267306-14-7;DA-56989;2-[2-(2-azidoethoxy)ethoxy]-N-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]acetamide;E83732;MS-28004;HY-137537;CS-0139831;2-(2-(2-AZIDOETHOXY)ETHOXY)-N-(2-(2,6-DIOXOPIPERIDIN-3-YL)-1,3-DIOXOISOINDOLIN-4-YL)ACETAMIDE;SCHEMBL23578881;Pomalidomide-PEG2-N3;AKOS040757513
SMILES: O=C1C(CCC(N1)=O)N1C(C2C=CC=C(C=2C1=O)NC(COCCOCCN=[N+]=[N-])=O)=O
Formula: C19H20N6O7
M.Wt: 444.398103713989
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Cat. No. Product name Field of application
DC68008 Tris-GalNAc-β-Ala-PEG3-FITC The trivalent β-GalNAc ligand is specific for Asialo Glycoprotein Receptors (ASGPR) on hepatocyte cells. β-Ala-PEG3 acts as linker/spacer between triantennary GalNAc and Fluorescein isothiocyanate (FITC).
DC68007 Tris-GalNAc-β-Ala-PEG3-MAL A thiol-reactive asialo glycoprotein receptor (ASGPR) ligand.
DC68006 Tri-GalNAc-PEG2000-DSPE Tris-GalNAc-GABA-NH2 linked via PEG2k to phospholipid (DSPE or 1,2-distearoyl-sn-glycero-3-phosphoethanolamine) where GABA = gamma-Aminobutyric acid, or γ-aminobutyric acid.
DC68005 Tris-GalNAc-PEG5-sulfo-NHS Ester An amine-reactive asialo glycoprotein receptor (ASGPR) ligand.
DC68004 Tris-GalNAc-β-Ala-PEG3-DBCO Triantennary GalNAc ligand is known to bind Asialo Glycoprotein Receptor (ASGPR). The ligand is functionalized with dibenzocyclooctyne for click chemistry.
DC68003 Tris-GalNAc-β-Ala-PEG4-DBCO Triantennary GalNAc ligand is known to bind Asialo Glycoprotein Receptor (ASGPR). The ligand is functionalized with dibenzocyclooctyne for click chemistry
DC68002 Tris-β-GalNAc-β-Ala-PEG3-N3 (β-D-GalNAc-sp)3-NHC(O)-(CH2)2-NHC(O)-PEG3-(CH2)2-N3 Tris-β-D-GalNAc ligands bind with asialoglycoprotein receptors (ASGPR) that are highly expressed on hepatocytes resulting in rapid endocytosis of the ligand along with conjugated payloads
DC68001 Tris-β-GalNAc-PEG3-Azide Trivalent β-GalNAc Ligand with discrete, monodisperse, azido-functionalized PEG3 linker/spacer
DC68000 Tris-GalNAc-β-Ala-PEG3-NH2
DC67999 Tris-GalNAc-Ahx-NH2
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