GENZ-644282(GENZ644282)|topoisomerase inhibitor|DC Chemicals

Cas No.:	529488-28-6
Chemical Name:	Genz-644282
Synonyms:	GENZ-644282;8,9-dimethoxy-2,3-methylenedioxy-5-[2-(N-methylamino)ethyl]-5H-dibenzo[c,h]1,6-naphthyridin-6-one;Genz644282;2,3-Dimethoxy-12-[2-(methylamino)ethyl]benzo[c][1,3]benzodioxolo[5,6-h][1,6]naphthyridin-13(12H)-one;Genz 644282;717I541I2R;AOB87160;BCP20983;SAR402674;SAR 402674;A13206;Q27265941;GENZ644282; GENZ 644282; SAR402674; ;2-Oxo-1-phenyl-1,2-dihydro-1,8-naphthyridine-3-carboxylic acid;GNZ-644282;http:////www.amadischem.com/proen/490526/;2,3-Dimethoxy-12-(2-(methylamino)ethyl)-[1,3]dioxolo[4',5':4,5]benzo[1,2-h]benzo[c][1,6]naphthyridin-13(12H)-one;CS-1525;EX-A481;HY-16228;NSC-768112;DTXSID301025941;16,17-dimethoxy-21-[2-(methylamino)ethyl]-5,7-dioxa-11,21-diazapentacyclo[11.8.0.0(2),(1)?.0?,?.0(1)?,(1)?]henicosa-1(13),2(10),3,8,11,14(19),15,17-octaen-20-one;AS-82896;16,17-dimethoxy-21-[2-(methylamino)ethyl]-5,7-dioxa-11,21-diazapentacyclo[11.8.0.02,10.04,8.014,19]henicosa-1(13),2,4(8),9,11,14,16,18-octaen-20-one;DA-42192;16,17-dimethoxy-21-[2-(methylamino)ethyl]-5,7-dioxa-11,21-diazapentacyclo[11.8.0.0^{2,10.0^{4,8.0^{14,19]henicosa-1(13),2,4(8),9,11,14,16,18-octaen-20-one;GLXC-10478;SCHEMBL241696;529488-28-6;AKOS030526835;CHEMBL191958;UNII-717I541I2R;GENZ644282; GENZ 644282; SAR402674; SAR 402674; SAR-402674;NSC768112;AMY27674;Benzo(C)(1,3)benzodioxolo(5,6-H)(1,6)naphthyridin-13(12H)-one, 2,3-dimethoxy-12-(2-(methylamino)ethyl)-;529488-28-6 (free base);AC-35477;A870863;8,9-dimethoxy-5-(2-N-methylaminoethyl)-2,3-methylenedioxy-5H-dibenzo(c,h)(1,6)naphthyridin-6-one;Topoisomerase I Inhibitor Genz-644282;BRD-K99475619-001-01-2
SMILES:	O1COC2=CC3C(C=C12)=C1C(=CN=3)C2C=C(C(=CC=2C(N1CCNC)=O)OC)OC
Formula:	C₂₂H₂₁N₃O₅
M.Wt:	407.419245481491
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Genz 644282 is a topoisomerase I inhibitor with an IC50 value of 0.4 nM in human bone marrow CFU-GM assay. The compound is a cytotoxic agent and shows activity in several human tumor cell lines.For the detailed information of GENZ-644282, the solubility of GENZ-644282 in water, the solubility of GENZ-644282 in DMSO, the solubility of GENZ-644282 in PBS buffer, the animal experiment (test) of GENZ-644282, the cell expriment (test) of GENZ-644282, the in vivo, in vitro and clinical trial test of GENZ-644282, the EC50, IC50,and Affinity of GENZ-644282, Please contact DC Chemicals.

Cat. No.	Product name	Field of application
DC7131	GENZ-644282	Genz-644282 is a non-camptothecin inhibitor of topoisomerase I with potential antineoplastic activity(IC50=1.2 nM).