I3MT-3|CAS 459420-09-8|DC Chemicals

Cas No.:	459420-09-8
Chemical Name:	I3MT-3
Synonyms:	4-Methyl-2-(2-Naphthalen-1-Yl-2-Oxidanylidene-Ethyl)sulfanyl-1~{h}-Pyrimidin-6-One;I3MT-3;GTPL10210;compound 3 [PMID: 28079151];4-methyl-2-(2-naphthalen-1-yl-2-oxoethyl)sulfanyl-1~{H}-pyrimidin-6-one;6-Methyl-2-((2-(naphthalen-1-yl)-2-oxoethyl)thio)pyrimidin-4(3H)-one;7NC;HMPSNE;starbld0000913;2-[(4-hydroxy-6-methylpyrimidin-2-yl)sulfanyl]-1-(naphthalen-1-yl)ethan-1-one;ZINC04370000;G17644;6-methyl-2-{[2-(naphthalen-1-yl)-2-oxoethyl]sulfanyl}-3H-pyrimidin-4-one;6-methyl-2-{[2-(naphthalen-1-yl)-2-oxoethyl]sulfanyl}-1H-pyrimidin-4-one;CS-0095460;AB00682589-01;HY-128206;4-methyl-2-(2-naphthalen-1-yl-2-oxoethyl)sulfanyl-1H-pyrimidin-6-one;459420-09-8;MS-24517;AKOS002376100;CHEMBL5092608;s3541;DA-54208
SMILES:	S(C1=NC(C)=CC(N1)=O)CC(C1=CC=CC2C=CC=CC1=2)=O
Formula:	C₁₇H₁₄N₂O₂S
M.Wt:	310.370262622833
Purity:	98%
Sotrage:	Please store the product under the recommended conditions in the Certificate of Analysis.

COA

MSDS

Cat. No.	Product name	Field of application
DC74454	aNDR1	aNDR1 (NDR1 agonist) is a specific small-molecule agonist of Nuclear Dbf2-related kinase 1 (NDR1, STK38), specifically inhibits CRPC cells and promotes kinase activity of NDR1.
DC70423	GA-017	GA-017 (GA017) is a potent, selective, ATP-competitive LATS kinase (LATS1/2) inhibitor with IC50 of 4.10/3.92 nM, respectively, promotes cell growth.GA-017 increases the number and size of spheroids of various cell-types in both scaffold-based and scaffold-independent cultures.GA-017 also enhances the ex vivo formation of mouse intestinal organoids.GA-017 facilitates the growth of spheroids and organoids by stabilizing and translocating YAP/TAZ into the cell nucleus.GA-017 inhibits the Hippo pathway to promote YAP/TAZ stabilization and nuclear translocation.GA-017 induces expression of Hippo pathway-related genes such as ANKRD1, CYR61, and CTGF in SKOV3 cells in a time- and dose-dependent manner.GA-017 inhibited the activity of 16 kinases of the AGC family at 100 nM against a panel of 321 diverse kinases.The serine/threonine protein kinases LATS (LATS1/2) phosphorylate YAP/TAZ, key effectors of the growth- and proliferation-regulating Hippo signaling pathway.
DC40375	I3MT-3	I3MT-3 (HMPSNE) is a potent, selective, and cell-membrane permeable inhibitor of 3-Mercaptopyruvate sulfurtransferase (3MST) (IC50=2.7 μM) and is inactive for other H2S/sulfane sulfur-producing enzymes.?I3MT-3 targets a persulfurated cysteine residue located in the active site of 3MST.