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| Cas No.: | 1191252-49-9 |
| Chemical Name: | 1,2,4-Oxadiazole-5-carboxamide,3-(3,5-dibromo-4-hydroxyphenyl)-N-[(4-phenoxyphenyl)methyl]- |
| Synonyms: | iOWH-032; IOWH032; IOWH 032 |
| SMILES: | BrC1=C(O)C(Br)=CC(C2=NOC(C(NCC3=CC=C(OC4=CC=CC=C4)C=C3)=O)=N2)=C1 |
| Formula: | C22H15Br2N3O4 |
| M.Wt: | 545.18 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | IOWH032 shows inhibitory activity against CFTR in T84-CFTR cell based assays with IC50 of 6.87 μM. In a mouse closed-loop model, IOWH032 causes a statistical significant inhibition against cholera toxin (CTX) induced secretion. IOWH032 (5 mg/kg) reduces the fecal output index by ~70% in a cecetomized rat model.For the detailed information of IOWH-032, the solubility of IOWH-032 in water, the solubility of IOWH-032 in DMSO, the solubility of IOWH-032 in PBS buffer, the animal experiment (test) of IOWH-032, the cell expriment (test) of IOWH-032, the in vivo, in vitro and clinical trial test of IOWH-032, the EC50, IC50,and Affinity of IOWH-032, Please contact DC Chemicals. |
MSDS
COA
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| 2018-0101 |
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