L-Carnitine hydrochloride ((R)-Carnitine hydrochloride) |cas 6645-46-1| DC Chemicals

Cas No.:	6645-46-1
Chemical Name:	(R)-3-Carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride
Synonyms:	(R)-3-Carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride;(r)-3-carboxy-2-hydroxy-n,n,n-trimethyl-1-;propanaminiumchloride;(r)-carnitinehydrochloride;3-carboxy-2-hydroxy-n,n,n-trimethyl-,chloride,(r)-1-propanaminiu;l-(3-carboxy-2-hydroxypropyl)trimethylammoniumchloride;lc-80;l-carnitinechloride;levocarnitinechloride;L-CARNITINE HYDROCHLORIDE, SYNTHETIC;(2R)- (9CI);1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-;chloride;(R)- 1-Propanaminium;3-carboxy-2-hydroxy-N,N,N-trimethyl-, chloride, (2R)-;(R)-(3-carboxy-2-hydroxypropyl)trimethylammonium chloride;[(2R)-3-carboxy-2-hydroxypropyl]-trimethylazanium,chloride;(?)-β-Hydroxy-γ-(trimethylammonio)butyrate;(R)-3-Hydroxy-4-(trimethylammonio)butyrate Hydrochloride;3-Hydroxy-4-(trimethylammonio)butanoate hydrochloride;Vitamine BT-hydrochloride;L(-)-Carnitine hydrochloride;L-Carnitine Hydrochloride
SMILES:	[Cl-].C(CC(O)C[N+](C)(C)C)(O)=O
Formula:	C₇H₁₆ClNO₃
M.Wt:	197.659841537476
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	L-Carnitine hydrochloride ((R)-Carnitine hydrochloride), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine hydrochloride is an antioxidant. L-Carnitine hydrochloride can ameliorate metabolic imbalances in many inborn errors of metabolism[1][2][3].
Target:	Human Endogenous Metabolite
In Vivo:	L-Carnitine hydrochloride ((R)-Carnitine hydrochloride) (125, 250 mg/kg; i.p.) has a more pronounced bronchodilator effect in this chronic murine asthma model, and decreases urinary LTE4 excretion[4]. Animal Model: 8- to 10-weeks-old and weighed 28-30g BALB/c mice[4] Dosage: 125, 250 mg/kg Administration: i.p. Result: SaO2 increased significantly at 250 mg/kg and decreased urinaryLTE4 excretion.
References:	[1]. Agarwal A, et al. Role of L-carnitine in female infertility. eprod Biol Endocrinol. 2018 Jan 26;16(1):5. [2]. Ferreira GC, et al. L-Carnitine and Acetyl-L-carnitine Roles and Neuroprotection in Developing Brain. Neurochem Res. 2017 Jun;42(6):1661-1675. [3]. Ferreira GC, et al. L-Carnitine and Acetyl-L-carnitine Roles and Neuroprotection in Developing Brain. Neurochem Res. 2017 Jun;42(6):1661-1675. [4]. Uzuner N, et al. The role of L-carnitine in treatment of a murine model of asthma. Acta Med Okayama. 2002 Dec;56(6):295-301.

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