LIPID 14|Ionizable Lipid for LNP

Cas No.:	2430034-05-0
Chemical Name:	lipid 14
Synonyms:	lipid-14， lipid14
SMILES:	O=C(OCCN(CCCCCCCCOC(C(CCCCCC)CCCCCCCC)=O)CCCCCCCCOC(C(CCCCCC)CCCCCCCC)=O)CCCN(C)C
Formula:	C₅₆H₁₁₀N₂O₆
M.Wt:	907.48
Purity:	>95%
Publication:	1 An Effective mRNA-LNP Vaccine Against the Lethal Plague Bacterium Edo Kon,Dan Peer, Ofer Cohen-doi: biorxiv, https://doi.org/10.1101/2022.08.07.503096 \|\|2 Elia, U.; Ramishetti, S.; Rosenfeld, R.; Dammes, N.; Bar-Haim, E.; Naidu, G. S.; Makdasi, E.; Yahalom-Ronen, Y.; Tamir, H.; Paran, N.;et al. Design of SARS-CoV-2 hFc-Conjugated Receptor-Binding Domain mRNA Vaccine Delivered via Lipid Nanoparticles. ACS Nano 2021 \|\|3 : A single-dose F1-based mRNA-LNP vaccine provides protection against the lethal plague bacterium E Kon, Y Levy, U Elia, H Cohen, I Hazan-Halevy… - Science Advances, 2023

Cat. No.	Product name	Field of application
DC60510	Iso-A11B5C1	Iso-A11B5C1 is an ionizable lipid. The iso-A11B5C1 LNP demonstrates a high level of muscle-specific mRNA delivery efficiency. exhibiting transfection efficiency comparable to the commercially available lipid SM-102, while considerably reducing inadvertent mRNA expression in main organs such as the liver and spleen.Additionally, study results show that intramuscular administration of mRNA formulated with iso-A11B5C1 LNP caused potent cellular immune responses, even with limited expression observed in lymph nodes.
DC82125	lipid 14	LIPID 14 is a novel ionizable lipid used for mRNA delivery.In 2021, Elia et al. used lipid 2 LNPs and lipid 14 LNPs to deliver mRNA encoding SARSCoV-2 human Fc-conjugated receptor binding domain (RBDhFc mRNA). While both lipid 274 LNP RBD-hFc mRNA and lipid 14 LNP RBD-hFc mRNA induced equal cellular and humoral responses in mice at an mRNA dose of 5 μg, only lipid 14 LNP RBD-hFc mRNA exhibited strong immunogenicity following intradermal administration. Both intradermal administration and intramuscular administration of lipid 14 LNPs could activate antigen presenting cells (APCs), thus inducing cellular responses.

lipid 14