LY-3039478|LY3039478|Purchase|DC CHEM

Cas No.:	1421438-81-4
Chemical Name:	Crenigacestat
Synonyms:	LY 3039478，LY-3039478，LY3039478
SMILES:	O=C(N[C@@H](C)C(N[C@H]1C2=CC=CC=C2C3=CC=CN=C3N(CCO)C1=O)=O)CCC(F)(F)F
Formula:	C₂₂H₂₃F₃N₄O₄
M.Wt:	464.44
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

LY3039478 is a small molecule that inhibits Notch signaling. LY3039478 potently inhibits mutant Notch receptor activity. In a xenograft tumor model, LY3039478 inhibited N1ICD cleavage and expression of Notch-regulated genes in the tumor microenvironment.. For the detailed information of LY-3039478, the solubility of LY-3039478 in water, the solubility of LY-3039478 in DMSO, the solubility of LY-3039478 in PBS buffer, the animal experiment (test) of LY-3039478, the cell expriment (test) of LY-3039478, the in vivo, in vitro and clinical trial test of LY-3039478, the EC50, IC50,and affinity,of LY-3039478, Please contact DC Chemicals.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC7776	LY-3039478	LY3039478 a orally bioavailable, novel small molecule Notch inhibitor with an IC50 of ~1nM in most of the tumor cell lines tested.
DC11862	BMS-906024	BMS-906024 is a highly potent, selective inhibitor of γ-secretase mediated signaling of Notch1/2/3/4 receptors with IC50 of 1.6/0.7/3.4/2.9 nM, respectively.