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MAK683-CH2CH2COOH

  Cat. No.:  DC28700   Featured
Chemical Structure
2639882-68-9
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More than 5000 active chemicals with high quality for research!
Field of application
MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design PROTAC EED degrader-1 and PROTAC EED degrader-2.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2639882-68-9
Chemical Name: 2-Pyridinepropanoic acid, 5-[5-[[(5-fluoro-2,3-dihydro-4-benzofuranyl)methyl]amino]-1,2,4-triazolo[4,3-c]pyrimidin-8-yl]-6-methyl-
Synonyms: 2-Pyridinepropanoic acid, 5-[5-[[(5-fluoro-2,3-dihydro-4-benzofuranyl)methyl]amino]-1,2,4-triazolo[4,3-c]pyrimidin-8-yl]-6-methyl-
SMILES: C1(CCC(O)=O)=NC(C)=C(C2=CN=C(NCC3=C4C(=CC=C3F)OCC4)N3C=NN=C32)C=C1
Formula: C23H21FN6O3
M.Wt: 448.45
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design PROTAC EED degrader-1 and PROTAC EED degrader-2.
In Vitro: MAK683-CH2CH2COOH inhibits Karpas422 cells with a GI50 of 14 nM for 14 days treatment[1].
References: [1]. Hsu JH, et al. EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex. Cell Chem Biol. 2019 Nov 26. pii: S2451-9456(19)30362-9.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
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DC28700 MAK683-CH2CH2COOH MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design PROTAC EED degrader-1 and PROTAC EED degrader-2.
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