NH2-PEG6-Boc |cas 1286281-32-0 DC Chemicals

Cas No.:	1286281-32-0
Chemical Name:	Amino-PEG6-t-butyl ester
Synonyms:	Amino-PEG6-t-butyl ester;tert-butyl 1-amino-3,6,9,12,15,18-hexaoxahenicosan-21-oate
SMILES:	CC(OC(CCOCCOCCOCCOCCOCCOCCN)=O)(C)C
Formula:	C₁₉H₃₉NO₈
M.Wt:	409.514867067337
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	NH2-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG6-Boc is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
Target:	PEGs Alkyl/ether Non-cleavable
In Vitro:	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
References:	[1]. Foley CA, et al. Assessing the Cell Permeability of Bivalent Chemical Degraders Using the Chloroalkane Penetration Assay. ACS Chem Biol. 2020 Jan 17;15(1):290-295. [2]. Kenneth John DIRICO, et al. Spliceostatin analogs. WO2014068443A1.

Cat. No.	Product name	Field of application
DC45712	Pomalidomide-amino-PEG3-NH2 hydrochloride	Pomalidomide-amino-PEG3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.
DC45710	Pomalidomide-amino-PEG5-NH2 hydrochloride	Pomalidomide-amino-PEG5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.
DC45705	Thalidomide-NH-PEG1-NH2 hydrochloride	Thalidomide-NH-PEG1-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
DC40565	KB02-COOH	KB02-COOH is a fragment of synthesis of ubiquitin E3 ligase ligand KB02. KB02 can be used in the synthesis of PROTAC, such as KB02-JQ1 and KB02-SLF.
DC28654	NH2-PEG6-Boc	NH2-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG6-Boc is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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