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PDK1 inhibitor

  Cat. No.:  DC9587  
Chemical Structure
1001409-50-2
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More than 5000 active chemicals with high quality for research!
Field of application
PDK1 inhibitor is a potent and selective inhibitor of PDK1 with potential as anticancer agent..
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1001409-50-2
Synonyms: 3-Pyridinecarboxamide, 1-[(3,4-difluorophenyl)methyl]-N-[(1R)-2-[(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)oxy]-1-phenylethyl]-1,2-dihydro-2-oxo-
SMILES: O=C(C1=CC=CN(CC2=CC=C(F)C(F)=C2)C1=O)N[C@H](C3=CC=CC=C3)COC4=CC=C(N5)C(NC5=O)=C4
Formula: C28H22F2N4O4
M.Wt: 516.4955
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: PDK1 inhibitor is a potent and selective inhibitor of PDK1 with potential as anticancer agent.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC28963 (R)-PS210 (R)-PS210, the R enantiomer of PS210 (compound 4h-eutomer), is a substrate-selective allosteric activator of PDK1 with an AC50 value of 1.8 μM. (R)-PS210 targets to the PIF-binding pocket of PDK1. PIF: The protein kinase C-related kinase 2 (PRK2)-interacting fragment.
DC28936 CRTh2 antagonist 3 CRTh2 antagonist 3 is a potent chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTh2) antagonist. CRTh2 antagonist 3 (compound 4) also enhances the activity of PDK1 toward a short peptide substrate, with an EC50 of 2 μM and a Kd of 8.4 μM. CRTh2 antagonist 3 has the potential for cardiovascular inflammation.
DC28345 PDK1-IN-RS2 PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor with a Kd of 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 by PDK1.
DC9587 PDK1 inhibitor PDK1 inhibitor is a potent and selective inhibitor of PDK1 with potential as anticancer agent..
DC11968 OSU-03013 A novel potent, orally active 3-phosphoinositide-dependent kinase-1 (PDK-1) with IC50 of 2 uM.
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