Cas No.: | 61-76-7 |
SMILES: | Cl.OC(C1=CC=CC(O)=C1)CNC |
Formula: | C9H14ClNO2 |
M.Wt: | 203.67 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | (R)-(-)-Phenylephrine hydrochloride is a phenylephrine (PE) and an α1-adrenoceptor agonistPhenylephrine (PE), an alpha-adrenergic agonist and promoter of hypertrophic growth in the ventricular myocyte, to activate the three best-characterized mitogen-activated protein kinase (MAPK) subfamilies, namely p38-MAPKs, SAPKs/JNKs (i.e. stress-activated protein kinases/c-Jun N-terminal kinases) and ERKs (extracellularly responsive kinases), in perfused contracting rat hearts. PE induced dose-dependent and fully reversible isometric contractions with a threshold concentration of 10 nM (n = 4), and an EC50 of 1 microM. |