(S)-Verapamil hydrochloride| cas 36622-28-3| DC Chemicals

Cas No.:	36622-28-3
Chemical Name:	S(-)-VERAPAMIL
Synonyms:	S(-)-VERAPAMIL;(S)-(-)-Verapamil Hydrochloride;(S)-(-)-Verapamil Hy;S(-)-VERAPAMIL HCL;S(−)-Verapamil hydrochloride hydrate;(S)-Verapamil hydrochloride
SMILES:	[Cl-].COC1C(OC)=CC(CCC([N+])CCC[C@@](C#N)(CC)C2C=C(OC)C(OC)=CC=2)=CC=1
Formula:	C₂₆H₃₇N₂O₄+^.Cl-
M.Wt:	477.03598
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	(S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells[1].
Target:	LTC4 Ca2+
In Vitro:	(S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) not the (R)-Verapamil hydrochloride potently induces the death of MRP1-transfected BHK-21 cells[1]. (S)-Verapamil hydrochloride is good active form and has the low bioavailability[1].
References:	[1]. Perrotton T, et al. (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1. J Biol Chem. 2007 Oct 26;282(43):31542-8. Epub 2007 Jul 22. [2]. Tannergren C, et al. St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism. Clin Pharmacol Ther. 2004 Apr;75(4):298-309.

Cat. No.	Product name	Field of application
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DC40870	Etalocib	Etalocib (LY293111), an orally active leukotriene B4 receptor antagonist, inhibits the binding of [3H]LTB4, with a Ki of 25 nM. Etalocib (LY293111) prevents LTB4-induced calcium mobilization with an lC50 of 20 nM. Etalocib (LY293111) induces apoptosis.
DC40582	Montelukast	Montelukast is a potent, selective and orally active antagonist of cysteinyl leukotriene receptor 1 (CysLT1). Montelukast can be used for the reseach of asthma and liver injury. Montelukast also has an antioxidant effect in intestinal ischemia-reperfusion injury, and could reduce cardiac damage.
DC28814	(S)-Verapamil hydrochloride	(S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells.