T0901317|T-0901317|LXR agonist

Cas No.:	293754-55-9
Chemical Name:	Benzenesulfonamide, N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-
Synonyms:	T0901317,T 0901317,T-0901317
SMILES:	C(S(N(CC(F)(F)F)C1=CC=C(C(O)(C(F)(F)F)C(F)(F)F)C=C1)(=O)=O)1=CC=CC=C1
Formula:	C₁₇H₁₂F₉NO₃S
M.Wt:	481.33
Purity:	>98%
Sotrage:	4°C for 1 year, -20°C for more than 2 years

Description:

T0901317 is a potent and selective agonist for LXR and FXR, with EC50s of 50 nM and 5 μM, respectively.

References:

[1]. Ding H et al. LXR agonist T0901317 upregulates thrombomodulin expression in glomerular endothelial cells by inhibition of nuclear factor?κB. Mol Med Rep. 2016 Jun;13(6):4888-96 [2]. Baranowski M et al. Insulin-sensitizing effect of LXR agonist T0901317 in high-fat fed rats is associated with restored muscle GLUT4 expression and insulin-stimulated AS160 phosphorylation. Cell Physiol Biochem. 2014;33(4):1047-5

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

Cat. No.	Product name	Field of application
DC9842	T0901317	T0901317 is a potent, high affinity liver X receptor (LXR) agonist (EC50 ~ 50 nM, Kd values are 7 and 22 nM for LXR-α and LXR-β respectively).