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Home > Inhibitors & Agonists > Ras-Raf-MAPK-ERK > p38 MAPK

TA-02

  Cat. No.:  DC9300   Featured
Chemical Structure
1784751-19-4
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More than 5000 active chemicals with high quality for research!
Field of application
TA-02 induces cardiomyocyte differentiation from human embryonic stem cells following mesoderm induction. Potently inhibits p38α, CK1δ and CK1ε (IC50 values are 20, 32 and 32 nM respectively).
Chemicals PropertiesBiological activity COAMSDSRelated productsDatasheet
Cas No.: 1784751-19-4
Chemical Name: TA-02 induces cardiomyocyte differentiation from human embryonic stem cells following mesoderm induction. Potently inhibits p38α, CK1δ and CK1ε (IC50 values are 20, 32 and 32 nM respectively).
Synonyms: TA-02,TA02，TA 02
SMILES: C1(C=CN=CC=1)C1=C(C2C=CC(F)=CC=2)N=C(C2C(F)=CC=CC=2)N1
Formula: C20H13F2N3
M.Wt: 333.33
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM.IC50 value: 20 nMTarget: p38TA-02 is a novel compound with similar cardiogenic properties asSB203580 and SB202190. TA-02 especially inhibits TGFBR-2.
COA
MSDS
Cat. No. Product name Field of application
DC7028 SB242235 SB-242235 is a potent and selective p38 MAP kinase inhibitor with IC50 of 1.0 uM.
DC9300 TA-02 TA-02 induces cardiomyocyte differentiation from human embryonic stem cells following mesoderm induction. Potently inhibits p38α, CK1δ and CK1ε (IC50 values are 20, 32 and 32 nM respectively).
DC7946 SKF-86002 SKF-86002 is a potent inhibitor of p38 MAP kinase wit IC50 of 0.5-1 uM; inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM).
DC1004 SB-203580 SB203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM and blocks PKB phosphorylation with IC50 of 3-5 μM.
DC7807 SB 239063 SB 239063 is a potent and selective p38 MAPK inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580.
DC2097 SB202190 SB 202190 is a pyridinyl imidazole that inhibits the p38 pathway.
DC5095 PD169316 PD169316 is a potent and selective p38 MAP kinase inhibitor
DC9681 Pamapimod（R-1503） Pamapimod（R-1503）is a novel p38 MAP kinase inhibitor.
DC8630 Ralimetinib 2MsOH(LY2228820) LY2228820 is a novel and potent p38MAPK inhibitor (the IC50 for p38αMAPK and p38βMAPK were 7 nM and 3 nM, respectively).
DC7836 Doramapimod (BIRB-796) BIRB 796 (Doramapimod) is a highly selective p38α MAPK inhibitor with Kd of 0.1 nM, 330-fold greater selectivity versus JNK2, weak inhibition for c-RAF, Fyn and Lck, insignificant inhibition of ERK-1, SYK, IKK2, ZAP-70, EGFR, HER2, PKA, PKC, PKCα/β/γ.
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