TH 588,TH588|MTH1 inhibitor|DC CHEMIMICALS

Cas No.:	1609960-31-7
Chemical Name:	TH588
Synonyms:	TH588;TH-588;N4-Cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine;TH 588;4-N-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine;N~4~-Cyclopropyl-6-(2,3-Dichlorophenyl)pyrimidine-2,4-Diamine;2GE;SYN5087;AOB2013;PNMYJIOQIAEYQL-UHFFFAOYSA-N;BCP10995;BDBM50152124;s7632;BC600732;AK316938;B5845;6-(2,3-Dichlorophenyl)-N4-cyclopropylpyrimid
SMILES:	ClC1C(=C([H])C([H])=C([H])C=1C1=C([H])C(=NC(N([H])[H])=N1)N([H])C1([H])C([H])([H])C1([H])[H])Cl
Formula:	C₁₃H₁₂Cl₂N₄
M.Wt:	295.1672
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	TH588 is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1(IC50= 5 nM) in cells.TH588 is highly selective towards MTH1, with no relevant inhibition of other members of the nudix protein family or a panel of 87 enzymes, GPCRs, kinases, ion channels and transporter. TH588 has been shown to selectively kill a variety of cancer cell lines and with in vivo activity shown for TH588 in SW480 colorectal and MCF7 breast tumour xenografts.
Target:	IC50 value: 5 nM [1] Target: MTH1 inhibitor
References:	[1]. Gad H, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014 Apr 10;508(7495):215-21.

Cat. No.	Product name	Field of application
DC71735	PCLX-001	PCLX-001 is an orally acitve, small-molecule, dual N-myristoyltransferase (NMT) inhibitor, with IC50s of 5 nM (NMT1) and 8 nM (NMT2), respectively.
DC7726	TH 588	TH588 represents a highly selective and cell-permeable small molecule inhibitor targeting MTH1 (NUDT1), a member of the nudix hydrolase family, with potent inhibitory activity (IC₅₀ ≈5 nM).
DC7725	TH 287	TH 287 is a first-in-class MTH1 inhibitor (IC50 value 5.0 nM) that selectively and effectively kills U2OS and other cancer cell lines, with considerably less toxicity towards several primary or immortalized cells.
DC7664	Quarfloxin (CX-3543)	Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity.
DC7810	CX-5461	CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA, has no effect on Pol II, and possesses 250-to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.
DC7959	BMH-21	BMH-21 is a small molecule DNA intercalator that binds ribosomal DNA and inhibits RNA polymerase I transcription; does not cause phosphorylation of H2AX.
DC4196	Bleomycin Sulfate	Bleomycin sulfate (Blenoxane) is a glycopeptide antibiotic and an anticancer agent for squamous cell carcinomas (SCC) with IC50 of 4 nM in UT-SCC-19A cells.