AS408|CAS 2378521-26-5|DC Chemicals

Cas No.:	2378521-26-5
Chemical Name:	6-bromo-N2-phenylquinazoline-2,4-diamine
Synonyms:	SCHEMBL21497084;2378521-26-5;6-bromo-N~2~-phenylquinazoline-2,4-diamine;M3J;GTPL11074;6-Bromo-N2-phenylquinazoline-2,4-diamine;EN300-28305167;BDBM50569875;AS408;CHEMBL4869271;6-bromo-2-N-phenylquinazoline-2,4-diamine;2,4-Quinazolinediamine, 6-bromo-N2-phenyl-
SMILES:	BrC1C=CC2C(C=1)=C(N)N=C(N=2)NC1C=CC=CC=1
Formula:	C₁₄H₁₁BrN₄
M.Wt:	315.167941331863
Purity:	98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

MSDS

Cat. No.	Product name	Field of application
DC73377	AS408	AS408 is a negative allosteric modulator of the β2-adrenergic receptor (β2AR) for both G-protein activation and arrestin recruitment (pKB=6.8, [35S]GTPγS binding assays), binds to a pocket formed by the membrane-facing surface of TM3 and TM5.
DC72880	Norepinephrine hydrochloride	Norepinephrine (Levarterenol; L-Noradrenaline) hydrochloride is a potent agonist of adrenergic receptor (AR). Norepinephrine activates α1, α2, β1 receptors.
DC72329	Upidosin	Upidosin (Rec 15/2739) is an α-1 adrenoceptor (α-1 AR) antagonist. Upidosin shows moderate selectivity for the α-1A AR subtype. Upidosin shows uroselectivity in urethra and prostate with a Kb value of 2-3 nM higher than in ear artery and aorta with a Kb value of 20-100 nM. Upidosin inhibits [3H]prazosin binding to cloned human α-1A adrenergic receptor. Upidosin can be used for the research of urethral obstruction.
DC49622	A-61603	A-61603 is a selective α1A-adrenergic receptor agonist. A-61603 increases the frequency of spontaneous Ca2+ transients in rat ventricular myocytes in vitro.
DC29046	Ritodrine hydrochloride	Ritodrine hydrochloride (DU21220 hydrochloride) is a β-2 adrenergic receptor agonist.
DC28370	Dabuzalgron	Dabuzalgron (Ro 115-1240) is an orally active and selective α-1A adrenergic receptor agonist for the treatment of urinary incontinence. Dabuzalgron protects against Doxorubicin-induced cardiotoxicity by preserving mitochondrial function.
DC28149	SR59230A hydrochloride	SR59230A hydrochloride is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively.
DC28121	CGP 20712 A	CGP 20712 A (CGP 20712 mesylate) is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 A exhibits ~10,000-fold selectivity over β2-adrenoceptors.
DC28102	SR59230A	SR59230A is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively.
DC28084	Hydroxybupropion	Hydroxybupropion is the major active metabolite of Bupropion. Hydroxybupropion is metabolized by CYP2B6.Bupropion is an atypical antidepressant and smoking-cessation agent. Hydroxybupropion inhibits norepinephrine uptake with an IC50 value of 1.7 μM. Hydroxybupropion is also a nACh receptor antagonis tis more potent than Bupropion .