Aurora kinase inhibitor-2|CAS 331770-21-9|DC Chemicals

Cas No.:	331770-21-9
Chemical Name:	Aurora kinase inhibitor-2
Synonyms:	Benzamide, N-[4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenyl]-;Aurora Kinase Inhibitor II;Aurora Kinase Inhibitor II NEW;N-[4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenyl]benzamide;4-(4'-Benzamidoanilino)-6,7-dimethoxyquinazoline;AC1O7M16;Anilinoquinazoline1;CBiol_002061;CHEMBL382590;K00590a;quinazoline deriv. 1;SureCN1066538;N-{4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenyl}benzamide;GTPL5930;4-(4′-Benzamidoanilino)-6,7-dimethoxyquinazoline;BDBM12403;Bio1_000347;HMS3229A17;Bio1_001325;Bio1_000836;Q27074624;N-[4-;Aurora kinase inhibitor-2
SMILES:	O(C)C1C(=CC2=C(C=1)C(=NC=N2)NC1C=CC(=CC=1)NC(C1C=CC=CC=1)=O)OC
Formula:	C₂₃H₂₀N₄O₃
M.Wt:	400.429904937744
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

MSDS

COA

Cat. No.	Product name	Field of application
DC45318	Aurora kinase inhibitor-2	Aurora kinase inhibitor-2 is a selective and ATP-competitive Aurora kinase inhibitor with IC50s of 310 nM and 240 nM for Aurora A and Aurora B, respectively.
DC44124	TAS-119	TAS-119 is a potent, selective and orally active Aurora A inhibitor with an IC50 of 1.0 nM. TAS-119 shows high selectivity for Aurora A over other protein kinases, including Aurora B (IC50 of 95 nM). TAS-119 has potent antitumor activites.
DC39107	SP-146	SP-146 is a potent, selective and non-ATP-competitive inhibitor of Aurora B with IC50 of 0.316 nM. SP-146 can be used for the research of triple negative breast cancer (TNBC).
DC1084	ZM447439 (ZM-447439)	ZM-447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively.
DC11370	TAK-901	TAK-901 is a non-selective Aurora kinase inhibitor (IC50s = 3.1, 10, and 4.2 nM for Aurora A, B, and C, respectively).
DC5111	PHA-680632	PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3.
DC9365	MLN8054	MLN8054 is a potent and selective inhibitor of Aurora A with IC50 of 4 nM; exhibits more than 40-fold selective for Aurora A than Aurora B.
DC7325	CYC116	CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM.