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Cyclic-di-GMP(c-di-GMP)

  Cat. No.:  DC28013   Featured
Chemical Structure
61093-23-0
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More than 5000 active chemicals with high quality for research!
Field of application
Cyclic di-GMP (c-di-GMP) is one of the most important and common bacterial second messenger. It is involved in numerous prokaryotic processes, including biofilm formation, motility, virulence, and cell cycling. c-di-GMP also has functions in eukaryotic cells. It is detected by the transmembrane protein stimulator of interferon genes (STING), leading to activation of the innate immune system.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 61093-23-0
Synonyms: CYCLIC DIGUANOSINE MONOPHOSPHATE ( C-DIGMP )3'-Guanylic acid,guanylyl-(3'®5')-,cyclic 3'®5'''-nucleotide;CYCLIC BIS ( 3' → 5' ) DIGUANYLIC ACID;5'''-nucleotide;bis(3',5')-cyclic diguanylic acid
SMILES: NC1=NC(=O)C2=C(N(C3OC4COP(OC5C(COP(OC4C3O)(O)=O)OC(N3C=NC4C(N=C(NC3=4)N)=O)C5O)(O)=O)C=N2)N1
Formula: C20H24N10O14P2
M.Wt: 690.41
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMS
Description: Cyclic-di-GMP is a STING agonist and a ubiquitous second messenger that regulates biofilm formation, motility, and virulence in diverse bacterial species.
Target: STING[1]
References: [1]. Nakamura T, et al. Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma. J Control Release. 2015 Oct 28;216:149-57. [2]. Burdette DL, et al. STING is a direct innate immune sensor of cyclic di-GMP. Nature. 2011 Sep 25;478(7370):515-8.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC28013 Cyclic-di-GMP(c-di-GMP) Cyclic di-GMP (c-di-GMP) is one of the most important and common bacterial second messenger. It is involved in numerous prokaryotic processes, including biofilm formation, motility, virulence, and cell cycling. c-di-GMP also has functions in eukaryotic cells. It is detected by the transmembrane protein stimulator of interferon genes (STING), leading to activation of the innate immune system.
DC28012 c-Di-AMP(Cyclic-Di-AMP) ammonium salt Bis-(3'-5')-cyclic dimeric adenosine monophosphate (c-di-AMP) is a bacterial second messenger implicated in the control of cell wall metabolism, osmotic stress responses and sporulation. Detection of c-di-AMP by the host cytoplasmic surveillance pathway (CSP) is known to elicit type I IFN responses through a signaling axis that involves STING, TBK1 and IRF3 [1, 2]. Involvement of the helicase DDX41 in the recognition of c-di-AMP has been suggested [3]. Recent studies have also demonstrated that c-di-AMP exerts strong adjuvant activities when delivered by the mucosal route [4, 5].
DC10959 STING inhibitor C-178 STING inhibitor C-178 is a covalent, small-molecule inhibitor of STING, blocks palmitoylation (PMA)-induced clustering of STING; covalently binds to Cys91, directly targets mouse STING (mmSTING) but not human STING (hsSTING).
DC10960 STING inhibitor C-176 STING inhibitor C-178 is a covalent, in vivo-active, small-molecule inhibitor of STING
DC10908 ML RR-S2 CDA ML RR-S2 CDA is a synthetic cyclic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds and is an activator of stimulator of interferon genes (STING).
DC10876 H-151 H-151(H151) is a novel STING (stimulator of interferon genes) antagonist.
DC12321 STING agonist-1 trihydrochloride diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes (STING) receptor agonist.
DC11642 Cridanimod sodium Cridanimod sodium is a potent type I interferon (IFN) inducer that directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route.
DC11641 Cridanimod A potent type I interferon (IFN) inducer that directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route.
DC12367 Cyclic guanosine monophosphate-adenosine monophosphate 2'3'-cGAMP has been used to identify small compounds capable of binding human stimulator of interferon genes (STING). It is also used to study type I interferon response to cytosolic DNA.
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