EDI048|CAS 2767264-57-1|DC Chemicals

Cas No.:	2767264-57-1
Chemical Name:	EDI048
Synonyms:	EDI048; EDI 048; EDI-048
SMILES:	O=C(OC)C1=CC(N(C(C2=CC3=C(C=NN3C=C2)C4=CC=C(C=C4)C(NC)=O)=O)C)=CC=C1Cl
Formula:	C₂₅H₂₁ClN₄O₄
M.Wt:	476.91
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC74605	EDI048	EDI048 (compound 1.16) is an orally active Cryptosporidium PI4K inhibitor for the research of cryptosporidiosis.
DC74270	GSK-3923868	GSK-3923868 (PI4KB inhibitor 30) is a potent, selective, slow-dissociating PI4KB (PI4kIII-beta) inhibitor with pKi of 9.8, >1000-fold selectivity over PI4KA, inhibits HRV viral replication in COPD BECs.
DC71906	CHMFL-PI4K-127	CHMFL-PI4K-127 (compound 15g) is an orally active, potent and high selective PfPI4K (Plasmodium falciparum PI4K kinase) inhibitor, with an IC50 of 0.9 nM. CHMFL-PI4K-127 exhibits potent activity against 3D7 Plasmodium falciparum, with an EC50 of 25.1 nM. CHMFL-PI4K-127 shows antimalaria efficacy.
DC8254	PIK-93	PIK-93 is the first potent, synthetic PI4K (PI4KIIIβ) inhibitor with IC50 of 19 nM; shown to inhibit PI3Kα with IC50 of 39 nM.
DC10061	PI4KA inhibitor-A1	GSK-A1 is a potent inhibitor of PI4KA. In vitro using HEK-AT1 cells, GSK-A1 had an IC50 of about 3 nM.