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exo-IWR-1

  Cat. No.:  DC44098  
Chemical Structure
1127442-87-8
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More than 5000 active chemicals with high quality for research!
Field of application
exo-IWR-1, an inactive stereoisomer of Endo-IWR-1, is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1127442-87-8
Chemical Name: exo-IWR-1
Synonyms: exo-IWR-1;exo-IWR 1;IWR-1 exo (IWR-1-exo, exo IWR-1);IWR-1-exo;4-[(3aR,4R,7S,7aS-rel)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-Methano-2H-isoindol-2-yl]-N-8-quinolinylbenzaMide
SMILES: C1=CC2=C(C(=C1)NC(=O)C3=CC=C(C=C3)N4C(=O)[C@@H]5[C@H]6C=C[C@H](C6)[C@@H]5C4=O)N=CC=C2
Formula: C25H19N3O3
M.Wt: 409.43700
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC44098 exo-IWR-1 exo-IWR-1, an inactive stereoisomer of Endo-IWR-1, is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway.
DC23893 Foxy-5(Wnt5a peptide mimetic) Foxy-5 is a novel Wnt-5A mimicking hexapeptide that inhibits breast cancer metastasis in vivo by targeting cell motility.
DC77212 NCB-0970 NCB-0970 is the negative control of NCB-0846. (R)-Norfluoxetine is a potent serotonin re-uptake inhibitor, with a Ki of 13 nM. (R)-Norfluoxetine can be used for the research of depression.
DC77211 EXQ-2d EXQ-2d is the inhibitor for tankyrase and inhibits TNKS1 and TNKS2 with an IC50 of 48.8 nM and 13.8 nM (pIC50=7.31 and 7.86). EXQ-2d inhibits WNT/β-catenin signaling pathway with IC50 of 515 nM. EXQ-2d exhibits anti-proliferative activity in cancer cells COLO 320DM and RKO with GI50 of 4.9 μM and 77 μM.
DC77210 BMD4503-1 BMD4503-1 is a quinoxaline derivative. BMD4503-1 can inhibit the LRP5/6-Sclerostin interaction and regulate the Wnt signaling pathway.
DC77209 21H7 21H7 is a selective inhibitor of the Wnt/b-catenin pathway. 21H7 markedly inhibits the growth of HFs. 21H7 potently decreases growth of breast and colon cancer cells.
DC77208 1(R),2(S)-epoxy Cannabidiol 1(R),2(S)-epoxy Cannabidiol (Compound 2a) is a structural analogue of phytocannabinoidsphytocannabinoids. 1(R),2(S)-epoxy Cannabidiol exhibits potent inhibitory activity against Wnt/β-catenin pathway. 1(R),2(S)-epoxy Cannabidiol is promising for research of neuroprotective agents.
DC74465 WNTinib WNTinib is a multi-kinase inhibitor with specificity against β-catenin (CTNNB1) mutant hepatocellular carcinoma, harnesses the KIT/MAPK/EZH2 pathway, shows durable and selective transcriptional repression of mutant β-catenin/Wnt targets through nuclear tr
DC74464 LPD-01 LPD-01 is a small molecule inhibitor of the Wnt/β-catenin signaling pathway, directly binds to importin7, inhibits the transactivation of target genes of the Wnt/β-catenin signaling pathway.
DC74463 ISQ-1 ISQ-1 is a potent in vitro inhibitor of several cancer cell lines (LS174T cell proliferation, IC50=100 nM), inhibits Wnt signaling and also activates adenosine monophosphate kinase (AMPK).
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