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Home > Inhibitors & Agonists > Membrane Transporter/Ion Channel > TRP Channel

GSK3527497

  Cat. No.:  DC70461   Featured
Chemical Structure
2215855-22-2
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More than 5000 active chemicals with high quality for research!
Field of application
GSK3527497 (GSK-3527497) is a potent, selective TRPV4 inhibitor with IC50 of 12 nM (hTRPV4).GSK3527497 is a pre-clinical candidate for treatment of diseases resulting from TRPV4 activation.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2215855-22-2
Chemical Name: GSK3527497
Synonyms: Benzonitrile, 4-[[(3S,4S)-4-(aminomethyl)-1-[(5-chloro-2-pyridinyl)sulfonyl]-4-hydroxy-3-pyrrolidinyl]oxy]-2-fluoro-
SMILES: C(#N)C1=CC=C(O[C@@H]2[C@@](CN)(O)CN(S(C3=NC=C(Cl)C=C3)(=O)=O)C2)C=C1F
Formula: C17H16ClFN4O4S
M.Wt: 426.849744796753
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC72365 BAY-390 BAY-390 is a selective, across species active and brain penetrating TRPA1 inhibitor. BAY-390 inhibits hTRPA1 FLIPR, hTRPA1 Ephys, rTRPA1 FLIPR and rDRG Ephys with IC50s of 16, 82, 63 and 35 nM, respectively.
DC70461 GSK3527497 GSK3527497 (GSK-3527497) is a potent, selective TRPV4 inhibitor with IC50 of 12 nM (hTRPV4).GSK3527497 is a pre-clinical candidate for treatment of diseases resulting from TRPV4 activation.
DC70460 GSK3395879 GSK3395879 (GSK-3395879) is a novel potent, selective, orally bioavailable antagonist of TRPV4 with IC50 of 1 nM (hTRPV4); exhibits little or no activity against a broad panel of TRP channels (IC50 > 10µM for TRPA1, TRPV1, TRPM2, TRPM4, TRPM8, TRPC3, TRPC4, TRPC5, TRPC6); demonstrates the ability to inhibit TRPV4-mediated pulmonary edema in an in vivo rat model.
DC11472 TRPM8 antagonist 14 TRPM8 Antagonist is a potent and selective TRPM8 antagonist, with an IC50 of 0.2 nM, used in the research of neuropathic pain syndromes.
DC7755 TRCP6 inhibitor(SAR7334) TRPC6 inhibitor is a potent TRPC6(Transient receptor potential cation channel, subfamily C, member 6) inhibitor.
DC9722 SKF96365 SKF96365 is blocker of TRP cation channels. Inhibits capacitative Ca2+ entry.
DC9635 SB-705498 SB-705498 is a potent, selective and orally bioavailable transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with a pIC50 of 7.1.
DC9735 SB-366791 SB-366791 is a selective and competitive VR1 (TRPV1) antagonist that is commonly used in pain research.
DC8306 RQ-00203078 RQ-00203078 is a potent TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively).
DC7262 Optovin Optovin is a reversible photoactive TRPA1 activator.
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