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HQ005

  Cat. No.:  DC72726   Featured
Chemical Structure
2750644-31-4
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More than 5000 active chemicals with high quality for research!
Field of application
HQ005 is a highly efficient molecular glue degrader that induces the selective degradation of ​Cyclin K (CCNK) with exceptional potency (DC50 = 41 nM). By facilitating novel protein-protein interactions between ​CCNK and the ​ubiquitin-proteasome system, HQ005 promotes targeted ubiquitination and proteasomal clearance of CCNK, offering a precise pharmacological tool for modulating ​CDK12/13-dependent transcription and ​DNA damage response pathways.
Cas No.: 2750644-31-4
Chemical Name: HQ005
SMILES: O=C(CC1=CSC(NC2=CC=CC(CO)=N2)=N1)NC3=NC=C(C)S3
Formula: C15H15N5O2S2
M.Wt: 361.44
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
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