MS934

  Cat. No.:  DC70620   Featured
MS934
Chemical Structure
2756323-15-4
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Field of application
MS934 (MS-934) is a VHL-recruiting MEK1/2 degrader (PROTAC) with HT29 DC50 of 18/9 nM for MEK1/2 degradation, respectively.MS934 is more potent at inhibiting the growth of HT-29, SK-MEL-28, H3122, and SUDHL1 cells. MS934 also displays good plasma exposure in mice.
Cas No.: 2756323-15-4
Chemical Name: (2S,4R)-1-((S)-22-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,20-dioxo-3-oxa-2,8,21-triazatricosan-23-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
Synonyms: MS-934;MS-934;MS 934
SMILES: FC1=CC=C(C(NOCCCCNCCCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N2C(C(N[C@@H](C)C3=CC=C(C4=C(C)N=CS4)C=C3)=O)CC(O)C2)=O)=O)=O)C(NC5=CC=C(I)C=C5F)=C1F
Formula: C52H69F3In7O6S
M.Wt: 1104.127
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: 1. Jianping Hu, et al. J Med Chem. 2020 Dec 24;63(24):15883-15905.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC70621 MS9715 MS9715 (MS-9715) is a NSD3-targeting PROTAC designed by linking BI-9321, a NSD3 antagonist, which binds NSD3's PWWP1 domain, with an E3 ligase VHL ligand.MS9715 achieves effective and specific targeting of NSD3 and associated cMyc node in tumor cells.MS9715 effectively suppresses growth of NSD3-dependent hematological cancer cells.MS 9715 effectively suppresses NSD3-and cMyc-associated gene expression programs, resembling effects of the CRISPR-Cas9-mediated knockout of NSD3.
DC70620 MS934 MS934 (MS-934) is a VHL-recruiting MEK1/2 degrader (PROTAC) with HT29 DC50 of 18/9 nM for MEK1/2 degradation, respectively.MS934 is more potent at inhibiting the growth of HT-29, SK-MEL-28, H3122, and SUDHL1 cells. MS934 also displays good plasma exposure in mice.
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