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NaV1.7 inhibitor 51

  Cat. No.:  DC70639  
Chemical Structure
2244153-85-1
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More than 5000 active chemicals with high quality for research!
Field of application
NaV1.7 inhibitor 51 is a highly potent, selective, orally active NaV1.7 inhibitor with IC50 of 10.7 nM in FLIPR membrane potential assay, no significant activity against NaV1.5 (IC50>10 uM).NaV1.7 inhibitor 51 shows good selectivity against other NaV isoforms and minimal inhibition at 10 uM for the resting state across different NaV isoforms.NaV1.7 inhibitor 51 exhibits state-dependent block of human, monkey, and mouse NaV1.7 with a similar potency range.NaV1.7 inhibitor 51 shows significant effects on the CCI-induced neuropathic pain model.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2244153-85-1
Chemical Name: NaV1.7 inhibitor 51
Formula: C24H20F3N5O2S
M.Wt: 499.512
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
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