NH-23-C2

  Cat. No.:  DC70648   Featured
NH-23-C2
Chemical Structure
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Field of application
NH-23-C2 (Caspase-2 inhibitor NH-23-C2) is a potent, selective and cell-permeable endogenous caspase-2 inhibitor, does not block caspase-3 or caspase-8.NH-23-C2 displays off-reactivity with cysteine and threonine proteases (cathepsins B, L, V, S).HCT116 cells were preincubated with NH-23-C2 inhibitor, MDM-2 cleavage was inhibited in a concentration-dependent manner (IC50 =3.11 μM).NH-23-C2 selectively block caspase-2 activity and caspase-2-mediated MDM-2 cleavage.
Cas No.:
Chemical Name: NH-23-C2
Synonyms: Caspase-2 inhibitor NH-23-C2
SMILES: O=C(O)CCC[C@H](NC([C@H]1NC2=C(C=CC=C2)C1)=O)C(N[C@@H]([C@H](OCC3=CC=CC=C3)C)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(COC(C4=C(C)C=CC=C4C)=O)=O)=O)=O)=O
Formula: C43H51N5O13
M.Wt: 845.903
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: 1. Marcin Poreba, et al. Cell Death Differ. 2019 Dec;26(12):2695-2709.
Description: NH-23-C2 (Caspase-2 inhibitor NH-23-C2) is a potent, selective and cell-permeable endogenous caspase-2 inhibitor, does not block caspase-3 or caspase-8.NH-23-C2 displays off-reactivity with cysteine and threonine proteases (cathepsins B, L, V, S).HCT116 cells were preincubated with NH-23-C2 inhibitor, MDM-2 cleavage was inhibited in a concentration-dependent manner (IC50 =3.11 μM).NH-23-C2 selectively block caspase-2 activity and caspase-2-mediated MDM-2 cleavage.
References: 1. Marcin Poreba, et al. Cell Death Differ. 2019 Dec;26(12):2695-2709.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC70648 NH-23-C2 NH-23-C2 (Caspase-2 inhibitor NH-23-C2) is a potent, selective and cell-permeable endogenous caspase-2 inhibitor, does not block caspase-3 or caspase-8.NH-23-C2 displays off-reactivity with cysteine and threonine proteases (cathepsins B, L, V, S).HCT116 cells were preincubated with NH-23-C2 inhibitor, MDM-2 cleavage was inhibited in a concentration-dependent manner (IC50 =3.11 μM).NH-23-C2 selectively block caspase-2 activity and caspase-2-mediated MDM-2 cleavage.
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