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NJH-2-057

  Cat. No.:  DC47935  
Chemical Structure
2858812-70-9
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More than 5000 active chemicals with high quality for research!
Field of application
NJH-2-057 is an EN523 OTUB1 recruiter linked to lumacaftor, a drug used to treat cystic fibrosis that binds ΔF508-CFTR.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2858812-70-9
Chemical Name: 3-[6-[[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropanecarbonyl]amino]-3-methylpyridin-2-yl]-N-[5-[3-[5-(2-oxo-4-prop-2-enoylpiperazin-1-yl)furan-2-yl]propanoylamino]pentyl]benzamide
Synonyms: CHEMBL5208354;NJH-2-057;MS-31501;EX-A8238;2858812-70-9
SMILES: FC1(OC2=CC=C(C=C2O1)C1(C(NC2C=CC(C)=C(C3C=CC=C(C(NCCCCCNC(CCC4=CC=C(N5C(CN(C(C=C)=O)CC5)=O)O4)=O)=O)C=3)N=2)=O)CC1)F
Formula: C43H44F2N6O8
M.Wt: 810.84167766571
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC72875 GLPG2451 GLPG2451 (GLPG 2451) is a potent potentiator of cystic fibrosis transmembrane conductance regulator (CFTR) with EC50 of 11 nM for F508del CFTR in the YHA assay and EC50 of 18 nM in TECC assay using HBE cells from patients carrying the F508del mutation. GLPG2451 improves the gating function of the CFTR channel.
DC70796 SRI-41315 SRI-41315 is a small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion, restores CFTR expression and function, suppresses CFTR nonsense mutations.SRI-41315 induces translational readthrough by depleting eRF1 protein level and prolonging the translational pause that occurs at premature termination codons (PTCs).SRI-41315 reduced eRF1 levels in a manner dependent upon a ubiquitin-mediated proteasome degradation pathway.SRI-41315 in combination with G418 restores CFTR function in primary bronchial epithelial cells derived from a CF patient with CFTR nonsense alleles.
DC48190 Vanzacaftor Vanzacaftor is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) for treating cystic fibrosis.
DC47935 NJH-2-057 NJH-2-057 is an EN523 OTUB1 recruiter linked to lumacaftor, a drug used to treat cystic fibrosis that binds ΔF508-CFTR.
DC11678 Galicaftor Galicaftor (ABBV-2222/GLPG-2222) is an orally bioavailable small molecule that functions as a CFTR corrector, demonstrating potential for therapeutic development in cystic fibrosis research.
DC12003 Corr4A A small molecule corrector of ΔF508-CFTR with IC50 of 6.0 uM..
DC72358 (R)-Olacaftor (R)-Olacaftor ((R)-VX-440) is a Cystic fibrosis transmembrane conductance regulator (CFTR) modulator. (R)-Olacaftor has good potential for the study of cystic fibrosis (CF).
DC72212 CFTR corrector 8 CFTR corrector 8 is a potent CFTR modulator. CFTR can be used in the research of cystic fibrosis.
DC72048 SRI-37240 SRI-37240 is a potent premature termination codons (PTCs) inhibitor. SRI-37240 suppresses CFTR nonsense mutations. SRI-37240 alters cellular translation termination at PTCs in HEK293T cells. SRI-37240 can also restore CFTR function in primary bronchial epithelial cells when combination with G418.
DC70237 Bamocaftor potassium Bamocaftor (VX-659) is a next-generation CFTR corrector, restores F508del-CFTR protein function.
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