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NNGH

  Cat. No.:  DC71092   Featured
Chemical Structure
161314-17-6
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More than 5000 active chemicals with high quality for research!
Field of application
NNGH is a stromelysin-1 (MMP-3) inhibitor. MMP-3 is both a direct transcriptional target and a necessary contributor of the Wnt/β-catenin signaling pathway. Matrix metalloproteinases (MMPs) play a well-defined role in later stages of tumor progression.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 161314-17-6
Chemical Name: NNGH
Synonyms: Acetamide,N-hydroxy-2-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-;NNGH;NNGH​;BML-205;N-Isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid;N-hydroxy-2-[(4-methoxyphenyl)sulfonyl-(2-methylpropyl)amino]acetamide;AcetaMide, N-hydroxy-2-[[(4-Methoxyphenyl)sulfonyl](2-Methylpropyl)aMino]-;N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID;AKOS040744915;NGH;Q27097492;N-Hydroxy-2-((N-isobutyl-4-methoxyphenyl)sulfonamido)acetamide;N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sulfonamido]acetamide;N-Isobutyl-N-(4-methoxyphenylsulfonyl)glycyl Hydroxamic Acid; N-Hydroxy-2-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]acetamide;;NNGH, >=98% (HPLC);1rmz;N-hydroxy-N~2~-[(4-methoxyphenyl)sulfonyl]-N~2~-(2-methylpropyl)glycinamide;J-009812;N-Hydroxy-2-(((4-methoxyphenyl)sulfonyl)(2-methylpropyl)amino)acetamide;CHEMBL-311932;NS00069310;MMP-3 Inhibitor II - CAS 161314-17-6;DS-017133;CS-0077845;CCG-207858;CHEMBL311932;HY-119711;NCGC00388616-04;SCHEMBL598146;BDBM13080;GLXC-01793;2-((4-Methoxyphenyl)sulfonyl-(2-methylpropyl)amino)-N-oxidanyl-ethanamide;Acetamide, N-hydroxy-2-(((4-methoxyphenyl)sulfonyl)(2-methylpropyl)amino)-;DB08271;161314-17-6;UNII-9P3H27MP46;N-hydroxy-2-((4-methoxyphenyl)sulfonyl-(2-methylpropyl)amino)acetamide;MMP-3 Inhibitor II;BML-205, N-Isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid;1z3j;9P3H27MP46;Acetamide,n-hydroxy-2-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-;Acetamide,n-hydroxy-2-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-;n-isobutyl-n-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid;n-isobutyl-n-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid;N-hydroxy-2-[N-(2-methylpropyl)4-methoxybenzenesulfonamido]acetamide;N-hydroxy-2-[N-(2-methylpropyl)4-methoxybenzenesulfonamido]acetamide;N-hydroxy-2-(N-(2-methylpropyl)4-methoxybenzenesulfonamido)acetamide;N-hydroxy-2-(N-(2-methylpropyl)4-methoxybenzenesulfonamido)acetamide
SMILES: CC(CN(S(=O)(C1=CC=C(OC)C=C1)=O)CC(NO)=O)C
Formula: C13H20N2O5S
M.Wt: 316.3733
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_35318_DC71092_161314-17-6
COA
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Cat. No. Product name Field of application
DC73746 BAY-9835 BAY-9835 is the first orally bioavailable ADAMTS7 inhibitor with IC50 of 6 nM, which is selective against a range of off-targets and metalloproteases except for ADAMTS12.
DC73744 ADAM9i ADAM9i is a specific small molecule inhibitor of ADAM9 protein with binding KD of 5.9 uM and enzyme IC50 of 5.2 uM, promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy.
DC71092 NNGH NNGH is a stromelysin-1 (MMP-3) inhibitor. MMP-3 is both a direct transcriptional target and a necessary contributor of the Wnt/β-catenin signaling pathway. Matrix metalloproteinases (MMPs) play a well-defined role in later stages of tumor progression.
DC70708 Prinomastat Prinomastat (AG3340) is a potent, selective MMP inhibitor with pM affinities for inhibiting gelatinases (MMP-2 and -9, Ki=50-150 pM), MMP-14 and MMP-13; demonstrates broad antitumor activity in a number of tumor models, inhibits glioma invasion or growth of the human malignant glioma cell line U87; also suppresses tumor growth in a malignant glioma tumor model.
DC70174 ADAM17 inhibitor SN-4 ADAM17 inhibitor SN-4 is a newly identified, highly specific inhibitor of ADAM17 (A disintegrin and metalloproteinase 17), demonstrating potent activity in blocking TNF-α cleavage in cellular assays with an IC50 value of 3.22 µM. This compound exhibits slightly greater efficacy compared to marimastat, a well-established ADAM17 inhibitor. In vitro studies reveal that SN-4 effectively suppresses ADAM17-mediated cleavage of tumor necrosis factor α (TNF-α) and CD44, while showing no significant impact on ADAM10 activity. Additionally, SN-4 has been shown to inhibit cellular invasion, highlighting its potential as a targeted therapeutic agent for modulating ADAM17-related pathways.
DC28782 MMP-9-IN-1 MMP-9-IN-1 is a specific matrix metalloproteinase-9 (MMP-9) inhibitor, which selectively target the hemopexin (PEX) domain of MMP-9, but not other MMPs.
DC28161 ARP-100 ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with S1＇ pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel. ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM), and MMP-9 (0.2 μM).
DC11355 MMP-3 Inhibitor MMP-3 inhibitor is a peptide inhibitor of matrix metalloproteinase-3 (MMP-3) with a Ki value of 95 nM.
DC11338 MMP-2/MMP-7 Fluorogenic Substrate Control Mca-PL is a fluorogenic peptide that has been used as a building block in the synthesis of Mca-PLGL-Dpa-AR-NH2, a fluorogenic substrate for matrix metalloproteinase-2 (MMP-2) and MMP-7.
DC12117 Luteolin 7-O-glucuronide (Luteolin 7-glucuronide4) Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively.
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