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PR-104

  Cat. No.:  DC45552  
Chemical Structure
851627-62-8
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More than 5000 active chemicals with high quality for research!
Field of application
PR-104 is a selective hypoxia-activated DNA cross-linking agent can be used for the research of multiple tumor xenograft models. PR-104 as a nitrogen mustard pre-prodrug is converted efficiently to the more lipophilic dinitrobenzamide mustards alcohol PR-104A.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 851627-62-8
Chemical Name: PR-104
SMILES: O=C(NCCOP(O)(O)=O)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1N(CCBr)CCOS(=O)(C)=O
Formula: C14H20BrN4O12PS
M.Wt: 579.27
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC47692 Colibactin 742 Colibactin 742, a stable colibactin derivative, induces DNA interstrand-cross-links, activation of the Fanconi Anemia DNA repair pathway, and G2/M arrest.
DC47691 Anticancer agent 11 Anticancer agent 11 is a broad-spectrum anticancer agent that inhibits angiogenesis and induces DNA cross-links.
DC47690 Methylnitronitrosoguanidine Methylnitronitrosoguanidine (MNNG) is an alkylating agent with toxic and mutagenic effects.
DC47042 Mipicoledine Mipicoledine is a potential neuro-alkylating agent for study of glioblastoma and metastatic cancers involving the central nervous system.
DC46827 (-)-Irofulven (-)-Irofulven (MGI 114), an Illudin S analog, is a DNA alkylating agent. (-)-Irofulven inhibits the replication of DNA, induces tumor cells apoptosis, and has potent antitumor activity.
DC46050 Lurbinectedin D3 Lurbinectedin D3 is deuterium labeled Lurbinectedin. Lurbinectedin (PM01183) is a DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively.
DC45553 PR-104 sodium PR-104 (sodium) is a selective hypoxia-activated DNA cross-linking agent can be used for the research of multiple tumor xenograft models. PR-104 (sodium) as a nitrogen mustard pre-prodrug is converted efficiently to the more lipophilic dinitrobenzamide mustards alcohol PR-104A.
DC45552 PR-104 PR-104 is a selective hypoxia-activated DNA cross-linking agent can be used for the research of multiple tumor xenograft models. PR-104 as a nitrogen mustard pre-prodrug is converted efficiently to the more lipophilic dinitrobenzamide mustards alcohol PR-104A.
DC45331 PR-104A PR-104A (SN 27858) is the alcohol metabolite of phosphate prodrug PR-104. PR-104A is a hypoxia-selective DNA cross-linking agent/DNA-damaging agent and cytotoxin. Antitumor Activity. PR-104A is metabolized under hypoxia by the 1-electron NADPH:cytochrome P450 oxidoreductase. PR-104A can be used for the research of relapsed/refractory T-lineage acute lymphoblastic leukemia (T-ALL).
DC41170 Busulfan-D8 Busulfan-D8 is a deuterium labeled Busulfan. Busulfan is an alkyl sulfonate that acts as an alkylating antineoplastic agent. Busulfan forms both intra- and interstrand crosslinks on DNA. In mammals, Busulfan causes profound and prolonged reduction in the generation of hematopoietic progenitors without significantly affecting lymphocyte levels or humoral antibody responses.
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