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RORγt inverse agonist 13

  Cat. No.:  DC44172   Featured
Chemical Structure
2170477-75-3
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More than 5000 active chemicals with high quality for research!
Field of application
RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist, with improved drug-like properties, with an IC50 of 63.8 nM.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2170477-75-3
Chemical Name: RORgammat inverse agonist 13
Synonyms: 4-[[[[[2,6-Dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]amino]carbonyl]amino]methyl]benzeneacetic acid;RORγt inverse agonist 13;RORgammat inverse agonist 13;ROR;At inverse agonist 13;BDBM441828;AKOS040759911;2170477-75-3;2-[4-[[[3,5-dichloro-4-[2-(trifluoromethoxy)phenyl]phenyl]carbamoylamino]methyl]phenyl]acetic acid;CS-0133430;ROR??t inverse agonist 13;HY-131338;RORgamma t inverse agonist 13;CHEMBL4786768;EX-A5894;MS-29526;SCHEMBL20943259;US10647665, Example 1-15;G17729;ZBAVYJYWRYFFEJ-UHFFFAOYSA-N
SMILES: ClC1C([H])=C(C([H])=C(C=1C1=C([H])C([H])=C([H])C([H])=C1OC(F)(F)F)Cl)N([H])C(N([H])C([H])([H])C1C([H])=C([H])C(C([H])([H])C(=O)O[H])=C([H])C=1[H])=O
Formula: C23H17Cl2F3N2O4
M.Wt: 513.2933
Purity: 98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
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DC47003 Bevurogant Bevurogant is a retinoid-related orphan receptor-gamma t (RORγt) antagonist. Bevurogant can be used for the research of chronic inflammatory diseases.
DC46880 Cedirogant Cedirogant (ABBV-157) is an orally active RORγt inverse agonist. Cedirogant can be used for psoriasis research.
DC44172 RORγt inverse agonist 13 RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist, with improved drug-like properties, with an IC50 of 63.8 nM.
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DC11846 TMP778 TMP778 (TMP-778) is a potent, selective RORγt inhibitor with IC50 of 7 nM in FRET assays and 63 nM in IL-17 promoter assays, with no inverse agonist activity.
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DC11047 MRL871 MRL-871 (MRL871) is a potent, selective inhibitor of RORγt via allosteric inverse agonism, inhibits coactivator binding with IC50 of 7 nM; significantly reduces the IL17a mRNA levels in EL4 murine lymphoblast cell line at 10 uM.
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